宜昌市部分地区HPV感染的流行病学研究

Epidemiological study on HPV infection status in some areas of Yichang City

目的分析宜昌市部分地区人乳头状瘤病毒(HPV)感染的流行病学特点,了解宜昌地区HPV感染现状。方法选取2015年12月22日-2017年9月29日三峡大学第二人民医院的3838例城区及农村女性,进行HPV分型检测。结果3838例女性中,HPV阳性860例,总检出率为22.41%。21种HPV亚型检出率排名从高至低依次为:HPV52(19.53%)、HPV16(18.14%)、HPV81(CP8304)(15.93%)、HPV58(15.58%)、HPV53(12.56%)、HPV51(8.37%)、HPV39(8.02%)、HPV33(7.09%)、HPV18(6.28%)、HPV68(4.65%)、HPV31(3.49%)、HPV6(3.49%)、HPV66(3.26%)、HPV56(2.44%)、HPV11(2.09%)、HPV59(1.86%)、HPV44(1.05%)、HPV35(0.93%)、HPV42(0.70%)、HPV43(0.58%)、HPV45(0.47%)。HPV单重感染647例,感染阳性率为16.86%;多重感染213例,感染阳性率为5.55%。高危型HPV感染670例,感染阳性率为17.46%;低危型HPV感染104例,感染阳性率为2.71%;高低危混合型HPV感染86例,感染阳性率为2.24%。所有年龄段女性HPV检出率排名从高至低依次为:41~50岁(29.42%)、31~40岁(25.70%)、21~30岁(22.67%)、51~60岁(14.77%)、≥61岁(5.58%)、≤20岁(1.86%)。结论宜昌市为HPV感染高发区且存在一定地域差异性。HPV分型检测应成为有性生活女性的妇科常规体检项目。对不同地区HPV感染现状的流行病学调查有助于研发和选用合适的HPV疫苗。

Objective To analyze the epidemiological characteristics of human papillomavirus(HPV)in some areas of Yichang City,understand the current situation of HPV infection in Yichang City.Methods A total of 3838 urban and rural women from the Second People's Hospital of China Three Gorges University from December 22nd,2015 to September,29th,2017 were selected for HPV genotype detection.Results Among 3838 women,the total detection rate of HPV was 22.41%(860 women).The detection rates of 21 kinds of HPV genotypes from high to low were HPV52(19.53%),HPV16(18.14%),HPV81(CP8304)(15.93%),HPV58(15.58%),HPV53(12.56%),HPV51(8.37%),HPV39(8.02%),HPV33(7.09%),HPV18(6.28%),HPV68(4.65%),HPV31(3.49%),HPV6(3.49%),HPV66(3.26%),HPV56(2.44%),HPV11(2.09%),HPV59(1.86%),HPV44(1.05%),HPV35(0.93%),HPV42(0.70%),HPV43(0.58%),HPV45(0.47%).The positive rates of HPV single infection and multiple infection were 16.86%(647 women)and 5.55%(213 women),respectively.The positive rates of high-risk HPV infection,low-risk HPV infection,mixed HPV infection were 17.46%(670 women),2.71%(104 women),and 2.24%(86 women),respectively.The detection rates of HPV from high to low among the women in different age groups were 41-50 years old(29.42%),31-40 years old(25.70%),21-30 years old(22.67%),51-60 years old(14.77%),≥61 years old(5.58%),and≤20 years old(1.86%),respectively.Conclusion Yichang City is a high incidence area of HPV infection,and there are some regional differences.HPV genotype detection should be a routine physical examination item for women having sexual life.The epidemiological investigation on HPV infection in different regions is helpful to develop and select appropriate HPV vaccine.