嘧啶并萘酰亚胺Ag^+荧光探针的合成及性能研究

Synthesis and Properties of Pyrimidine Naphthalimide-based Ag^+ Fluorescent Probes

以4-硝基-1,8-萘酐为起始原料,经硝化、还原和亲核加成制得N-丁基-4,5-二氨基-1,8-萘酰亚胺,继而与2-呋喃甲醛缩合得到标题化合物嘧啶并萘酰亚胺衍生物,其结构经1HNMR、13CNMR、HR-MS和元素分析确证。光谱研究表明,标题化合物对Ag+具有较好的选择性和适中的响应时间,在502 nm处发生荧光猝灭,荧光强度与银离子浓度的关系为y=-4.64873x+392.331,检测限为1.56×10-6 mol/L。

4-Nitro-1,8-naphthalene anhydride was used as raw material to prepare N-butyl-4,5-diamino-1,8-naphthalimide by nitration,reduction and nucleophilic addition reaction,and then,the condensation reaction with furaldehyde was performed to obtain the pyrimido-naphthylimide derivative.The structure of the title compound was confirmed by 1HNMR,13CNMR,HR-MS and elemental analysis.Optical studies showed that the title compound had good selectivity and proper response time for Ag+and the fluorescence quenched at 502 nm.The relationship between fluorescence intensity and Ag+concentration was y=-4.64873x+392.331,and the detection limit was 1.56×10-6 mol/L.