N6-甲基腺苷(m6A)修饰调控配子发生、胚胎发育和性别决定的研究进展

Advances in the regulation of gametogenesis,embryonic development and sex determination by N6-methyladenosine(m6A)modification

N6-甲基腺苷(m6A)是真核生物mRNA中含量最为丰富的甲基化修饰形式,甲基转移酶(writers)、脱甲基酶(erasers)、甲基结合蛋白(readers)3种蛋白共同保证着m6A的动态可逆修饰。最近的研究显示,m6A的差异表达与配子发生相关,并且对胚胎发育和性别决定也显示出重要作用。对m6A的研究明显改变了对胚胎种植、分化和发育的认识,为此,本文就m6A与配子发生、胚胎发育及性别决定的相关研究进行综述。

N6-methyladenosine(m6A)is the most abundant methylation modification form in eukaryotic mRNA.Methyl transferase(writers),demethylase(erasers)and methyl binding protein(readers)jointly guarantee the dynamic reversible modification of m6A.Recent studies have shown that differential expression of m6A is associated with gametogenesis and plays an important role in embryo development and sex determination.The study of m6A has significantly changed the understanding of embryo implantation,differentiation and development.Therefore,this paper reviews the related studies on m6A and gametogenesis,embryo development and sex determination.