期刊文献+

替格瑞洛改善氯吡格雷抵抗急性心肌梗死治疗的疗效分析 被引量:1

下载PDF
导出
摘要 目的:探讨替格瑞洛改善氯吡格雷抵抗急性心肌梗死治疗的疗效。方法:选取我院2018年1月—2019年1月共110例氯吡格雷抵抗急性心肌梗死患者,随机分为对照组和试验组,各55例。对照组术后给予氯吡格雷与阿司匹林药物,试验组术后给予替格瑞洛与阿司匹林药物。结果:治疗前,两组超敏C反应蛋白与P选择素比较,差距不具有统计学意义(P>0.05)。治疗后,两组超敏C反应蛋白与P选择素指标均优于治疗前,但试验组指标改善优于对照组(P<0.05)。两组在不良反应发生率方面比较,试验组出现呼吸不畅、心肌梗死、心绞痛与脑卒中发生率低于对照组(P<0.05)。结论:针对氯吡格雷抵抗急性心肌梗死应用替格瑞洛药物不仅治疗安全性高,有效性强,还可减少药物对机体损伤,符合临床需求,值得推广。
作者 凌静
出处 《北方药学》 2020年第6期34-35,共2页 Journal of North Pharmacy
  • 相关文献

参考文献5

二级参考文献29

  • 1郑心田,李广平.1961例急性心肌梗死发病年龄和性别分布分析[J].临床心血管病杂志,2007,23(4):312-313. 被引量:17
  • 2陈灏珠,钟南山,陆再英.内科学[M].8版.北京:人民卫生出版社,2013:624-626.
  • 3Young-Hoon Jeong,Kevin P. Bliden,Mark J. Antonino,Ki-Soo Park,Udaya S. Tantry,Paul A. Gurbel.Usefulness of the VerifyNow P2Y12 assay to evaluate the antiplatelet effects of ticagrelor and clopidogrel therapies[J].American Heart Journal.2012(1)
  • 4Refai Showkathali,Arun Natarajan.Antiplatelet and Antithrombin Strategies in Acute Coronary Syndrome: State-Of-The-Art Review[J].Current Cardiology Reviews.2012(3)
  • 5Jose Diez,B Lombo.Ticagrelor: the evidence for its clinical potential as an oral antiplatelet treatment for the reduction of major adverse cardiac events in patients with acute coronary syndromes[J].Core Evidence (default).2011(default)
  • 6Stefan James,Axel ?kerblom,Christopher P. Cannon,H?kan Emanuelsson,Steen Husted,Hugo Katus,Allan Skene,Philippe Gabriel Steg,Robert F. Storey,Robert Harrington,Richard Becker,Lars Wallentin.Comparison of ticagrelor, the first reversible oral P2Y 12 receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial[J].American Heart Journal.2009(4)
  • 7Thuy Anh Nguyen,Jean G. Diodati,Chantal Pharand.Resistance to clopidogrel: A review of the evidence[J].Journal of the American College of Cardiology.2005(8)
  • 8Lombo B,Diez JG.Ticagrelor:the evidence for its clinical potential as an oral antiplatelet treatment for the reduction of major adverse cardiac events in patients with acute coronary syndromes[J].Core Evid,2011,12(6):31-42.
  • 9DiN icolantonio JJ,Tomek A.Inactivations,deletions,non-adjudications,and downgrades of clinical endpoints on ticagrelor:serious concerns over the reliability of the PLATO trial[J].Int J Cardiol,2013,168(4):4076-4080.
  • 10Steg PG,James SK,Atar D,et al.ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation[J].Eur Heart J,2012,33(20):2569-2619.

共引文献105

同被引文献7

引证文献1

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部