盐酸多奈哌齐联合阿立哌唑对首发精神分裂症患者NSE、S100B蛋白水平的影响

Effect of donepezil hydrochloride combined with aripiprazole on NSE and S100B protein levels in first-episode schizophrenia patients

目的探究盐酸多奈哌齐联合阿立哌唑对首发精神分裂症患者NSE、S100B蛋白水平的影响。方法选取2019年6月至7月玉林市第四人民医院收治的100例首发精神分裂症患者,按随机数字表法分为观察组和对照组,各50例。对照组患者给予阿立哌唑片治疗,观察组患者则联合盐酸多奈哌齐片治疗,治疗周期均为12周。比较两组患者治疗后临床疗效;治疗前后血清NSE、S100B蛋白水平;治疗前、治疗4~12周认知功能评分及治疗期间不良反应发生率。结果观察组患者治疗后临床总有效率为90.00%,高于对照组的72.00%;与治疗前比,治疗后两组患者血清NSE、S100B蛋白水平均降低,且观察组低于对照组;治疗后两组患者4~12周CDT评分均逐渐升高,且观察组高于对照组;观察组患者治疗期间不良反应总发生率为24.00%,低于对照组的60.00%(均P<0.05)。结论盐酸多奈哌齐联合阿立哌唑能够有效降低首发精神分裂症患者血清NSE、S100B蛋白水平,提高患者的认知功能,疗效显著,且安全性较高。

Objective To explore the effect of donepezil hydrochloride combined with aripiprazole on NSE and S100B protein levels in patients with first-episode schizophrenia.Methods From June 2019 to July 2019,100 first-episode schizophrenics patients admitted to Yulin Fourth People’s Hospital were divided into observation group and control group with 50 cases in each group according to the method of random number table.The patients in control group were treated with aripiprazole tablets,and the patients in observation group were treated with donepezil hydrochloride tablets.The treatment cycle was 12 weeks.The clinical efficacy after treatment;the serum NSE and S100B protein levels before and after treatment;the cognitive function score before treatment and 4 to 12 weeks after treatment and the incidence of adverse reactions during treatment were compared between the two groups of patients.Results After treatment,the total clinical effective rate of the observation group was 90.00%,higher than 72.00%of the control group;compared with before treatment,the serum NSE and S100B protein levels of the two groups after treatment were lower,and the observation group was lower than the control group;the CDT scores of the two groups 4 to 12 weeks after treatment were gradually increased,and the observation group was higher than the control group;the incidence of adverse reactions of the observation group during treatment was 24.00%,which was lower than 60.00%of the control group(all P<0.05).Conclusion Donepezil hydrochloride combined with aripiprazole can effectively reduce the serum NSE and S100B protein levels in patients with first-episode schizophrenia,improve the cognitive function of patients,with significant efficacy and higher safety.