期刊文献+

非甾体类抗炎药联合人工泪液对干眼症患者泪液IL-6、TNF-α水平的影响 被引量:1

下载PDF
导出
摘要 目的探讨非甾体类抗炎药联合人工泪液对干眼症患者泪液IL-6、TNF-α水平的影响。方法选取2018年3月至2019年8月延边第二人民医院收治的干眼症患者108例,按随机数字表法分为两组,即观察组(n=54)和对照组(n=54)。对照组患者采用人工泪液治疗,观察组患者采用非甾体类抗炎药联合人工泪液治疗,两组患者均治疗15 d。比较治疗后两组患者临床疗效、泪液炎性因子水平、泪膜破裂时间、泪液分泌试验结果。结果治疗后观察组患者临床疗效(94.44%)高于对照组(81.48%)(P<0.05);治疗后两组患者泪液IL-6、TNF-α水平较治疗前降低,观察组降低幅度大于对照组(P<0.05);与治疗前比,治疗后两组患者泪膜破裂时间、泪液分泌试验滤纸条的浸湿长度均延长,且观察组长于对照组(P<0.05)。结论非甾体类抗炎药联合人工泪液可降低干眼症患者泪液IL-6、TNF-α水平,减轻患者炎性症状,利于患者康复,疗效显著。
作者 南美兰
出处 《现代医学与健康研究电子杂志》 2020年第3期34-35,共2页 Modern Medicine and Health Research
  • 相关文献

参考文献5

二级参考文献56

  • 1Malaisse J .Bourguignon V .De Vuyst E,et al. Hyaluronan metabolism in human keratinocytes and atopic dermatitis skin is driven by a balance of hyaluronan synthases 1 and 3[J]. J Invest Dermatol, 2014,134(8) : 2174-2182.
  • 2Midgley AC, Bowen T, Phillips AO, et al. MicroRNA-7 inhibition rescues age-associated loss of epidermal growth factor receptor and hyaluronan-dependent differentiation in Iibroblasts[J], Aging Cell, 2014,23 (2) : 235-244.
  • 3Lopez-Garcia JS, Garcia-Lozano I, Rivas L, et al. Autolo?gous serum eye drops diluted with sodium hyaluronate: clinical and experimental comparative study [J].. Acta Ophthalmol , 2014,92 (1) : 22-29.
  • 4Yamamoto A, Shimizu Nv Kuroyanagi Y. Potential of wound dressing composed of hyaluronic acid containing epidermal growth factor to enhance cytokine production by fibroblasts [J]. J . Art if Organs,2013,16(4) :489-494.
  • 5Chris toffer 0, H enrik LA, Birgi t S, et al. Phacoemulsifica?tion cataract sllrgeryin a large cohort of diabetes patients: Visual acuity outcomes and prognostic factors[J]. J Cata?ract Refract Surg, 2011,37 (11) : 2006-2012.
  • 6Mostafa S,Seamen V , Azzarolo AM. Influence of sex hor?mones and genetic predisposition in sjogrens syndrome s a new clue to the immunopathogenesis of dry eye disease [J]. Exp Eye Res, 2012,96 (1) : 88-97.
  • 7Kufelt 0, El-Tamer A, Sehring C, et al. Hyaluronic acid based materials for scaffolding via two-photon polymeri?zation[J]. Biomacromolecules, 2014,15 (2) : 650-659.
  • 8Chen D , Wei Y, Li X, et al. sPLA2- II a is an inflammatory mediator when the ocular surface is compromised[J]. Exp Eye Res, 2009 ,88 (5) : 880-888.
  • 9Linna TU,Vesaluoma MH,Perez-Santonja JJ,et al. Effect of my- opic LASIK on corneal sensitivity and morphology of subbasal nerves[J]. Invest Ophthalmol Vis Sci,2000,41(2):393-397.
  • 10Gmthe C, Nikkhah G.The role of basic flbroblust growth factor in peripheral nerve regeneration [J]. Anat Embryol, 2001,204 (3) : 171-177.

共引文献137

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部