血清胃泌素及胃蛋白酶原在芜湖地区部分健康体检人群中的表达及意义

Expression and significance of serum gastrin and pepsinogen in some healthy people undergoing physical examination in Wuhu area

目的探讨血清胃泌素、胃蛋白酶原水平在健康体检人群中的表达情况及意义。方法对参与体检的表观健康人群10012例采用酶联免疫法(ELISA)分别测定空腹血清胃泌素17(G-17)及胃蛋白酶原(PG)水平,计算血清G-17、PG中位数水平。结果不同性别PGⅠ、PGⅡ、PGR和G-17检测水平比较显示,男性PGⅠ、PGⅡ、PGR检测水平均高于女性,差异有统计学意义(P<0.05),而女性G-17检测水平高于男性,差异有统计学意义(P<0.05)。不同年龄段PGⅠ、PGⅡ、PGR和G-17检测水平差异均有统计学意义(P<0.001),PGⅠ、PGⅡ、G-17检测水平随年龄的增加而增加(P<0.001),而PGR检测水平随年龄的增加而下降(P<0.001)。结论健康体检人群中,血清胃泌素、胃蛋白酶原水平受性别、年龄的影响,判定胃泌素、胃蛋白酶原异常需结合以上因素综合考量。

Objective To investigate the expression and significance of serum gastrin and pepsinogen levels in healthy people undergoing physical examination.Methods The levels of fasting serum gastrin 17(G-17)and pepsinogen(PG)in 10012 apparently healthy people who participated in physical examination were measured by Enzyme-linked Immunosorbent Assay(ELISA)method,and the median serum G-17 and PG were calculated.Results The comparison of PGⅠ,PGⅡ,PGR and G-17 measurements between males and females showed that PGⅠ,PGⅡ and PGR measurements in males were higher than those of females,the difference was statistically significant(P<0.05),while females’G-17 measurements were higher than those of males,the difference was statistically significant(P<0.05).The differences in measurements of PGⅠ,PGⅡ,PGR and G-17 among different age groups were statistically significant(P<0.001),and PGⅠ,PGⅡ,G-17 measurements increased with the increase of age(P<0.001),while the measurements of PGR decreased with the increase of age(P<0.001).Conclusion In healthy people undergoing physical examination,serum gastrin and pepsinogen levels are affected by gender and age,so the diagnosis of gastrin and pepsinogen abnormalities should be considered comprehensively in combination with the above factors.