乌司他丁辅助胰岛素强化治疗糖尿病酮症酸中毒临床疗效观察

Clinical Efficacy of Ulinastatin-assisted Insulin Intensive Therapy in the Treatment of Diabetic Ketoacidosis

目的:观察乌司他丁辅助胰岛素强化治疗糖尿病酮症酸(DKA)的临床疗效。方法:随机将2018年9月~2019年12月在某院就诊的92例DKA患者分为A、B两组(A=46,B=46),A组接受胰岛素强化治疗,B组加用乌司他丁,比较两组血糖恢复正常时间、尿酮体转阴时间和pH纠正时间,对比两组治疗前后空腹血糖(FPG)、糖化血红蛋白(HbAlc)、血乳酸(Lac)、血清β-羟丁酸(β-HB)水平。结果:B组血糖恢复正常时间、尿酮体转阴时间、pH纠正时间均早于A组(P<0.05);B组治疗后FPG、HbAlc、Lac、β-HB水平均低于A组(P<0.05)。结论:乌司他丁辅助胰岛素强化治疗DKA临床疗效较好,可快速降低患者FPG、HbAlc、Lac、β-HB水平,具有临床推广价值。

Objective:To observe the clinical efficacy of ulinastatin-assisted insulin intensive therapy in the treatment of diabetic ketoacidosis(DKA).Methods:92 cases of DKA patients admitted to a hospital from September 2018 to December 2019 were randomly divided into two groups(A=46,B=46).The group A received intensive insulin treatment,and group B received ulinastatin on the basis of group A treatm.The blood glucose recovery time,urine acetone bodies recovery time and pH correction time were compared between the two groups.The levels of fasting blood glucose(FPG),glycosylated hemoglobin(HbAlc),blood lactic acid(Lac),and serum lactobutyric acid(β-HB)levels before and after treatment were compared between the two groups.Results:The blood glucose recovery time,urine acetone bodies recovery time and pH correction time were all earlier in group B than those in group A(P<0.05).After treatment,the levels of FPG,HbAlc,Lac andβ-HB in group B were all lower than those in group A(P<0.05).Conclusion:Ulinastatin-assisted insulin intensive therapy in the treatment of DKA has a good clinical effect,which can rapidly reduce FPG,HbAlc,Lac and beta-hb levels in patients,and has clinical promotion value.