联用TCT和HPV原位杂交检测对宫颈癌及癌前病变检出率的影响分析

Analysis of the effect of TCT and HPV in situ hybridization on the detection rate of cervical cancer and precancerous lesions

目的:探讨联用TCT和HPV原位杂交检测对宫颈癌及癌前病变检出率的影响。方法:选取在本院接受宫颈癌及癌前病变筛查的1230例女性为研究对象,均采用TCT和HPV原位杂交联合检测,同时对其进行病理组织活检。结果:根据病理组织活检结果,本组1230例患者中为阳性的患者有59例,阳性率为4.80%;TCT和HPV原位杂交联合检测中阳性的患者有56例,阳性率为4.55%,病理组织活检的阳性率与联合检测的阳性率比较差异无统计学意义(P>0.05)。TCT和HPV原位杂交联合检测的诊断准确率为94.92%(56/59),漏诊率为5.08%(3/59)。结论:TCT和HPV原位杂交联合检测在宫颈癌及癌前病变的筛查中具有较高的应用价值,可以提高宫颈癌及癌前病变的检出率和诊断准确率。

Objective:To investigate the effect of TCT and HPV in situ hybridization on the detection rate of cervical cancer and precancerous lesions.Methods:1230 women who were screened for cervical cancer and precancerous lesions in our hospital were selected as the study objects.TCT and HPV in situ hybridization were performed in all the selected subjects,and pathological biopsy was performed.Results:According to the results of pathological biopsy,59 of 1230 women were positive,the positive rate was 4.80%.The positive rate of TCT and HPV in situ hybridization was 4.55%.There was no significant difference between the positive rate of pathological biopsy and that of combined detection(P>0.05).The diagnostic accuracy of TCT and HPV in situ hybridization was 94.92%(56/59),and the missed diagnosis rate was 5.08%(3/59).Conclusion:The combination of TCT and HPV in situ hybridization has high application value in the screening of cervical cancer and precancerous lesions,which can improve the detection rate and diagnostic accuracy of cervical cancer and precancerous lesions.