摘要
DNA/银纳米簇(DNA/Silver nanoclusters,DNA/Ag NCs)是以DNA为模板,NaBH4和银离子为反应物生成的一种新型荧光纳米材料。近年来,银纳米簇以其出色的光物理性质、良好的生物相容性、低成本、低毒性等优点成为了生物传感器设计及应用研究的一个热点。对DNA/银纳米簇介导的生物传感器的信号输出方式进行分类,并总结了DNA/Ag NCs在体内成像和抑菌方面的应用;最后,对DNA/Ag NCs介导的生物传感器目前存在的不足及今后的发展趋势进行了展望。
DNA/Silver nanocluster(DNA/Ag NCs)is a novel fluorescent nanomaterial produced by using DNA as a template and NaBH4 and silver ions as reactants.In recent years,silver nanoclusters have become a hotspot in the design and applications of biological sensors due to their excellent photophysical properties,fine biocompatibility,low cost and low toxicity.The signal output methods in DNA/silver nanocluster-mediated biosensor are categorized,and the applications of DNA/Ag NCs in vivo imaging and bacteriostasis are also summarized.Finally,the shortcomings of DNA/Ag NCs-mediated biosensors and their future development trends are prospected.
作者
杨敏
李舒婷
杨文平
李相阳
许文涛
YANG Min;LI Shu-ting;YANG Wen-ping;LI Xiang-yang;XU Wen-tao(School of Food Science and Engineering,Beijing Agricultural College,Beijing 100083;Beijing Food Nutrition and Human Health Advanced Innovation Center,China Agricultural University,Beijing 100083)
出处
《生物技术通报》
CAS
CSCD
北大核心
2020年第6期245-254,共10页
Biotechnology Bulletin
基金
科技计划一般项目(KM201910020002)。
关键词
荧光
银纳米簇
生物传感器
功能核酸
fluorescence
silver nanoclusters
biosensors
functional nucleic acids
