我院2016—2019年辅助用药不良反应分析

Analysis of adverse reactions of auxiliary drugs in our hospital from 2016 to 2019

目的:探讨我院2016—2019年辅助用药不良反应的特点,为临床合理使用辅助用药提供参考。方法:对我院2016年7月—2019年7月上报的353例药物不良反应及47例辅助用药不良反应进行回顾性分析。结果:353例不良反应中,女性药物不良反应占比较多。考虑人口年龄分布及年龄跨度,≥60岁药物不良反应发生率最高,而呼吸系统疾病药物不良反应在各类疾病中最多。2016年7月15日—2017年7月14日药物不良反应137例,辅助用药不良反应26例,占比18.98%;2017年7月15日—2018年7月14日药物不良反应93例,辅助用药不良反应14例,占比15.05%;2018年7月15日—2019年7月14日药物不良反应123例,辅助用药不良反应7例,占比5.69%。ADR发生率最高的辅助用药类为中成药辅助用药,不良反应占比31.91%,肠外营养制剂ADR占比25.53%,营养神经类ADR占比12.77%,肿瘤辅助用药类ADR占比8.52%,维生素类为2.13%及其他为19.14%。47例辅助用药ADR中,主要为静脉滴注给药40例(85.11%)其次为口服给药7例(14.89%),肌注0例。新的严重的ADR 1例(2.13%),新的一般的ADR 20例(42.55%),一般的ADR 26例(55.32%),严重的ADR 0例。结论:中成药类、肠外营养类、营养神经类这三大类药物占我院辅助用药ADR的七成,我院应重点监测及规范使用上述三大类辅助用药,尽量减少辅助用药不良反应,使辅助用药使用安全、有效、合理、经济。

Objective:To explore the characteristics of adverse reactions of auxiliary drugs in our hospital from 2016 to 2019,and to provide reference for rational use of auxiliary drugs in clinic.Methods:All 353 cases of adverse drug reactions and 47 cases of auxiliary adverse drug reactions reported in our hospital from July 2016 to July 2019 were analyzed retrospectively.Results:In all 353 adverse reactions,there were more adverse drug reactions in female patients.Considering the population age distribution and the age span,the incidence of adverse drug reactions in the 60-year-old patients is the highest,and the adverse reaction of the drug in the respiratory system is the most in all kinds of diseases.2017.7.15 to 20187.14 The adverse reaction of the drug was 93 cases,and the adverse reaction of the auxiliary medication was 14 cases,accounting for 15.05%;20187.15 to 20197.14123 cases of adverse drug reactions,7 cases of auxiliary adverse drug reactions,the highest incidence of 5.69%.ADR auxiliary drugs,the proportion of adverse reactions was 31.91%,parenteral nutrition agent ADR accounted for 25.53%,nutritional nerve ADR accounted for 12.77%,tumor auxiliary drugs ADR accounted for 8.52%,the proportion of adverse reactions was 31.91%,the proportion of parenteral nutrition preparations was 25.53%,the proportion of nutritional nerve ADR was 12.77%,the proportion of adjunctive drugs was 8.52%.Vitamins were 2.13%and 19.14%.Among 47 cases of ADR,40 cases(85.11%)were given intravenous drip,and 7 cases(14.89%)were given oral administration.There were 0 cases of intramuscular injection.1 case of new severe ADR(2.13%),20 cases of new general ADR(42.55%),26 cases of general ADR(55.32%),0 cases of severe ADR.Conclusion:Proprietary Chinese medicine,parenteral nutrition and nutritional nerve account for 70%of ADR in our general hospital.Therefore,our hospital should focus on monitoring and standardizing the use of the above three kinds of auxiliary drugs,so as to reduce the occurrence of adverse reactions of auxiliary drugs as far as possible and make the use of auxiliary drugs safe,effective,reasonable and economical.