白蛋白对新生儿不明原因严重高胆红素血症疗效的研究

Effect of albumin on neonates with severe hyperbilirubinemia of unknown cause

目的探讨白蛋白联合蓝光光疗对新生儿不明原因严重高胆红素血症的治疗效果。方法回顾性分析2017年12月至2019年12月在我院治疗的60例新生儿不明原因严重高胆红素血症为研究对象,按照医生建议患者自愿选择是否应用白蛋白治疗为原则分为观察组和对照组各30例。对照组单纯采用蓝光照射进行治疗,观察组采用蓝光照射联合白蛋白治疗,比较两组患儿的临床疗效以及治疗前后的血清C反应蛋白、总胆红素、胆红素下降率、住院时间。结果观察组患儿治疗的总有效率为93.3%(28/30),明显高于对照组73.3%(22/30),差异有统计学意义(P<0.05)。观察组总胆红素、C反应蛋白及住院时间均显著低于对照组,胆红素下降率显著高于对照组,差异有统计学意义(P<0.05)。结论蓝光照射联合白蛋白在治疗新生儿不明原因严重高胆红素血症方面有着显著的疗效且无增加潜在感染风险,安全有效。

Objective To study the treatment effect of albumin combined with blue light phototherapy on neonates with severe hyperbilirubinemia of unknown cause.Methods Totally 60 neonates with severe hyperbilirubinemia of unknown cause treated in our hospital from Dec.2017 to Dec.2019 were included as research subjects.A retrospective analysis was performed.The subjects were assigned into observation group(30)and control group(30)according to whether the patients would like to receive albumin treatment on doctors’advice.The control group was treated only with blue light phototherapy,while the observation group received albumin besides the phototherapy.The following items were compared between the two groups:clinical effect after treatment,and the C-reactive protein,total bilirubin and reduction rate of bilirubin before and after treatment,and length of hospital stay.Results The total effective rate of observation group was 93.3%(28/30),which was significantly higher than that of control group was(73.3%,22/30)(P<0.05).The total bilirubin,C-reactive protein and length of hospital stay in observation group were significantly lower than those in control group,and the reduction rate of bilirubin was significantly higher,the difference being statistically significant(P<0.05).Conclusion The blue light phototherapy combined with albumin has significant effect in the treatment of neonates with severe hyperbilirubinemia of unknown cause without increasing the potential risk of infection.