公民逝世后器官捐献供肾损伤相关分子标志物的研究进展

Research progress on molecular markers related to the donor kidney injury from organ donation after citizen’s death

供肾短缺是肾移植面临的一大难题,对供肾功能的准确评估可以降低器官的弃用率,以挽救更多的尿毒症患者。与病理学检查相比,循环中的分子标志物检测在临床应用中较为方便。本文就目前已发现的肾损伤标志物血清肌酐和血清胱抑素C(Cys-C)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、肝型脂肪酸结合蛋白(L-FABP)、线粒体DNA(mtDNA)、肾损伤分子-1(KIM-1)和白细胞介素-18(IL-18)等方面的研究进展进行简要介绍。

Shortage of donor kidney is a major problem in renal transplantation.Accurate evaluation of donor kidney function may reduce the organ rejection rate and save more patients with uremia.Compared with pathological examination,detection of circulating molecular markers is more convenient in clinical application.In this article,the research progress on the markers of kidney injury,such as serum creatinine,serum cystatin C(Cys-C),neutrophil gelatinase-associated lipocalin(NGAL),liver-type fatty acid-binding protein(L-FABP),mitochondrial DNA(mtDNA),kidney injury molecule-1(KIM-1)and interleukin-18(IL-18),were briefly reviewed.