铁蛋白轻链在非小细胞肺癌中的表达及意义

Expression and significance of ferritin light chain in non-small cell lung cancer

目的探究铁蛋白轻链(FTL)在非小细胞肺癌(NSCLC)组织中的表达情况及其与NSCLC患者临床病理特征和预后的关系。方法收集2008年至2018年天津大学宝坻区人民医院病理科NSCLC组织标本,采用免疫组化检测61例NSCLC组织和51例癌旁组织中FTL的表达水平,并分析FTL与NSCLC患者临床病理学特征之间的关系,利用Kaplan-Meier Plotter在线数据库分析FTL的表达水平与NSCLC预后的相关性。结果 FTL在癌组织中表达明显高于癌旁组织(χ~2=16.859,P<0.01)。FTL在癌组织中表达水平与NSCLC患者临床病理特征无明显相关性(P>0.05)。Kaplan-Meier Plotter在线数据库生存分析结果显示,FTL高表达与NSCLC患者较差的总生存时间(OS)相关[P=0.0008,HR=1.27(1.10~1.45)],而与患者无进展生存时间(PFS)无关。FTL表达水平与肺腺癌患者OS及PFS均相关,其表达越高患者生存越差[P=0.0000,HR=2.20(1.69~2.86);P=0.0005,HR=1.74(1.27~2.40)];在肺鳞癌患者中FTL表达与OS及PFS均无关。在临床分期中,截尾值为OS时,FTL表达仅与临床Ⅰ期和Ⅱ期患者预后相关[P=0.0000,HR=2.12(1.56~2.87);P=0.0000,HR=2.22(1.49~3.32)];截尾值为PFS时,FTL仅与Ⅰ期患者预后相关[P=0.0154,HR=1.74(1.11~2.74)]。结论 FTL表达与NSCLC患者临床病理特征无关,而FTL高表达与NSCLC患者不良预后相关,FTL可用于评估NSCLC患者预后。

Objective To investigate the expression of ferritin light chain(FTL)in non-small cell lung cancer(NSCLC)tissues and its relationship with clinicopathological characteristics and prognosis of NSCLC patients.Methods By immunohistochemistry(IHC)method,the expression level of FTL in NSCLC and para-cancerous tissues was detected,and its relationship with the clinicopathological characteristics of NSCLC patients was analyzed.The correlation between FTL expression level and prognosis of NSCLC was analyzed by Kaplan Meier plotter online database.Results The expression level of FTL in cancer tissues was significantly higher than that in adjacent tissues(χ2=16.859,P<0.01).There was no significant correlation between the expression level of FTL in cancer tissues and the clinicopathological characteristics of NSCLC patients(P>0.05).Survival analysis of Kaplan-Meier Plotter online database showed that high expression of FTL was correlated with poor overall survival(OS)of NSCLC patients[P=0.0008,HR=1.27(1.10-1.45)],but not with progression-free survival time(PFS).In patients with lung adenocarcinoma,FTL expression was statistically correlated with OS[P=0.0000,HR=2.20(1.69-2.86)]and PFS[P=0.0005,HR=1.74(1.27-2.40)],and the higher the expression,the worse the survival.However,the expression of FTL was not associated with OS and PFS in patients with lung squamous-cell carcinoma.As the censored value for OS,the expression of FTL was only related to the prognosis of patients with clinical stageⅠandⅡ[(P=0.0000,HR=2.12(1.56-2.87);P=0.0000,HR=2.22(1.49-3.32)].As the cutoff value for PFS,FTL was only related to the prognosis of patients with stageⅠ[P=0.0154,HR=1.74(1.11-2.74)].Conclusion High expression of FTL is not associated with clinicopathological features but associated with poor prognosis in NSCLC patients.FTL can be used to evaluate the prognosis of NSCLC patients.