植入型给药系统的应用与发展趋势

Application and Development Trend of Implantable Drug Delivery System

植入型给药系统是缓控释给药系统的重要分支之一,适用于长期给药和靶向给药,具有载药量高、体积较小、作用时间长、副作用小、生物利用度高等特点,同时还可以大大提高长期慢性病患者的依从性,因此愈来愈被行业所重视。随着品种类型、给药途径及生产技术不断发展,植入型给药系统目前已被应用于生殖健康、肿瘤治疗、疼痛治疗、眼部治疗等众多领域。对近几年国内外植入剂的种类及临床研究和应用进展进行综述,为该剂型后续深入研究提供参考。

The implantable drug delivery system is one of the important components of the sustained and controlled release drug delivery system.It is suitable for long-term administration and targeted drug delivery with the characteristics of high drug loading,small size,long duration time,few side effects and high bioavailability,and can also greatly improve the compliance of patients with chronic diseases,so it has attracted more and more attention from the pharmaceutical industry.With the continuous development of their various types,routes of administration and production technology,implants have been applied to many fields such as reproductive healthcare and the treatment of cancer,pain and ocular diseases.By reviewing the types of implants and clinical research application and development at home and abroad in recent years,this paper intends to provide reference for further in-depth study on this dosage form.