急性心肌梗死患者血清中剪切型X-盒结合蛋白1表达与糖尿病及其他临床因素的相关性

Correlation analysis of serum XBP-1S expression with diabetes and its clinical multiple factors in patients with acute myocardial infarction

目的分析急性心肌梗死(AMI)患者入院24 h内血清中剪切型X-盒结合蛋白1(Spliced x box binding protein 1,XBP-1S)浓度与患者基本资料、临床指标及影像学指标的相关性。方法按XBP-1S血清浓度中位数164.7 pg/ml,将AMI患者86例分成2组:低表达组(<164.7 pg/ml,n=43)和高表达组(≥164.7 pg/ml,n=43),收集患者基本资料,临床资料和冠状动脉造影影像学资料进行组间比较。XBP-1S血清浓度与资料间的相关分析;结果组间比较发现高表达组糖尿病患病率显著高于低表达组(P <0.05);高表达组与低表达组两组冠状动脉粥样硬化病变血管分支数构成比有相关关系(P <0.05);XBP-1S血清浓度与血管的分支数呈正相关。结论在糖尿病患病率高的患者组中AMI起病急性期内血清中XBP-1S可能表达增高明显,并且与病变血管的分支数呈正相关。

AIM To explore the correlation between spliced x box binding protein 1(XBP-1 S) serum concentration and basic information, clinical indicators, and imaging of patients with acute myocardial infarction within 24 hours of admission. METHODS A total of 86 patients were admitted for acute myocardial infarction. Median XBP-1 S serum concentration was 164.7 pg/ml. Patients were divided into two groups: a low expression group(< 164.7 pg/ml, n = 43) and a high expression group( ≥ 164.7 pg/ml,n = 43). Basic, clinical and coronary angiography data of the patients were collected for correlation analysis. RESULTS Comparison between groups found that the prevalence of diabetes mellitus in the high-expression group was significantly higher than that in the low-expression group(P < 0.05);there was a correlation between the number of coronary atherosclerotic lesions in the high-expression and lowexpression groups(P < 0.05);XBP-1 S serum concentration was positively correlated with the number of branches of blood vessels. CONCLUSION In patients with a high prevalence of diabetes mellitus, the expression of XBP-1 S in serum may be significantly increased during the acute phase of AMI onset, and it is positively correlated with the number of branches of diseased blood vessels.