冠蛋白:肿瘤诊断的潜在靶点

Coronin,a novel potential target in tumor

冠蛋白(coronin)是位于细胞膜下方呈冠状结构的蛋白,由于它具备特殊的结构能与肌动蛋白结合,在胚胎发育和上皮细胞的迁移过程中扮演重要的角色。近年来随着对coronin家族研究的不断深入,发现其与微丝结合后能通过不同的分子机制影响肿瘤细胞的增殖和迁移;并且其表达水平的异常直接影响患者的预后。因此,对coronin的功能和分子机制的研究是目前的热点之一。我们将阐述coronin家族成员的结构特征及相应功能,总结并讨论其在当前各类肿瘤研究中的进展与潜在的应用前景。

Coronin,a protein has a coronal-like pattern and locates below the cell membrane.Owing to its particular structure,coronin plays a key role in embryonic development and epithelial cell migration via its binding to microfilaments.Recently,proteins in coronin family were demonstrated that they could regulate the proliferation and migration of tumor cells through a series of molecular mechanisms,and there was a positive relationship between its abnormal expression and prognosis in the clinical patients.Therefore,its function and role in the progress of tumorigenesis is a hot topic in the current field of tumor research.In this paper,we made a comprehensive description of its molecular structural features,summarized its different roles in tumors,and predict its potential therapeutic prospects in the future.