颈源性眩晕患者静息态脑功能连接研究

Research on Resting-State Functional Connectivity in Patients with Cervical Vertigo

目的通过静息态功能磁共振分析方法,研究颈源性眩晕(CV)患者脑区间长程功能连接和局部相邻神经元之间短程连接的特异性改变。方法通过CONN软件计算31例CV患者和25名正常对照(NC)基于AAL模板116个脑区任意两个脑区间的功能连接,对每条连接进行两组间独立双样本t检验(P<0.05,错误发现率校正);与此同时,通过DPABI软件计算两组各被试的zReHo指标值并做组间独立双样本t检验(P<0.01,cluster P<0.05,高斯随机场理论校正),随后,对有组间显著差异的功能连接和zReHo指标值分别与眩晕障碍量表(DHI)评分及其3个亚量表[躯体得分(PS)、情绪得分(ES)、功能得分(FS)]进行线性回归相关分析。结果相比NC组,CV组分别有6条显著增强和减弱的功能连接。CV组左侧辅助运动区的zReHo值相比NC组显著增加,而双侧内侧额上回的zReHo值相比NC组显著减弱。CV组左侧额中回与Vermis45间功能连接和ES显著正相关(r=0.4624,P<0.0115),左侧辅助运动区与Vermis3间功能连接和PS显著正相关(r=0.4338,P<0.0187)。CV组相比NC组具有显著改变的zReHo值与各临床量表评分均不存在相关性。结论CV组左侧辅助运动区和左侧前辅助运动区局部神经元间短程连接的改变及其与其他脑区间长程功能连接的改变一定程度上解释了CV患者躯体控制能力减弱的原因,其显著改变的功能连接与临床量表评分间的相关性可以尝试作为影像学指标以辅助对CV展开更进一步的认识。

Objective To study the specific changes of long-range functional connections and short-range connections between local adjacent neurons in patients with cervical vertigo(Cervical Vertigo-CV)by resting functional magnetic resonance analysis.Methods Using the CONN software to calculate the functional connections of any two brain regions of 116 brain regions based on the AAL template in 31 CV patients and 25 normal controls(Normal Controls-NC).Each connection was subjected to an independent two-sample T test between the two groups(P<0.05,error detection rate correction);At the same time,the zReHo index value of each group of two groups was calculated by DPABI software and an independent two-sample T test between groups(P<0.01,cluster P<0.05,Gaussian random field theory Correction),and then,the functional connections and zReHo index values with significant differences between the groups were successively scored with the Dizziness Disorder Scale Score(DHI)and its subscale,body score(PS),mood score(ES),function score(FS)Linear regression correlation analysis.Results We obtained six increased and six decreased functional connections in CV compared to NC.Meanwhile,zReHo value in left Supplementary Motor Area(lSMA)of CV was significantly increased compared to NC.However,in bilateral Superior Frontal Gyrus(medial)(SFGmed),zReHo values were significantly decreased in CV.Notably,two of the decreased connections were correlated with clinical scale scores.Particularly,functional connectivity between left Middle Frontal Gyrus(lMFG)and Vermis45 was positively correlated with emotion score(r=0.4624,P<0.0115).Functional connectivity between lSMA and Vermis3 was positively correlated with physical score(r=0.4338,P<0.0187).Conclusion Altered long range functional connections which involved lSMA and lSFGmed and the alteration of zReHo values of the two brain regions might explain to a certain extent the reason for the weakened body control ability of CV patients The correlation between significantly changed functional connections and clinical scale scores can be tried as an imaging index to assist in further understanding of CV.