肥胖儿童血糖、血脂代谢指标特征及其和性早熟的相关性分析

Characteristics of blood glucose and blood lipid metabolism in obese children and their correlation with precocious puberty

目的:探究肥胖儿童的血糖与血脂代谢特征,并分析其与儿童性早熟的相关性。方法:2017年3月-2019年1月选取行健康体检的肥胖儿童125例(肥胖组)及体重正常的儿童125例(正常组)进行研究,检查儿童的性发育情况,比较两组性早熟发生率、体重指数(BMI)、总胆固醇(TC)、甘油三酯(TG)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)水平。结果:肥胖组性早熟发生率高于正常组,性早熟儿童的平均BMI指数、TC、TG、FPG、HbA1c水平高于肥胖组,肥胖组平均BMI、TC、TG、FPG、HbA1c水平高于正常组,差异均有统计学意义(P<0.05)。结论:肥胖儿童的性早熟发生率较高,正常儿童、肥胖儿童、性早熟儿童的血糖与血脂代谢指标水平呈递增趋势,可见血糖、血脂的升高可促进儿童性早熟。

Objective:To explore the metabolic characteristics of blood glucose and blood lipids in obese children,and to analyze their correlation with precocious puberty.Methods:From March 2017 to January 2019,125 obese children who underwent physical examination(the obese group)and 125 children with normal weight(the normal group)were selected.The sexual development of children was examined,and the incidence of precocious puberty,body mass index(BMI),total cholesterol(TC),triglyceride(TG),fasting blood glucose(FPG)and glycosylated hemoglobin(HbA1c)levels were compared between the two groups.Results:The incidence of precocious puberty in obese group was higher than that in normal group,and the average BMI index,TC,TG,FPG and HbA1c in precocious puberty children were higher than those in obese group,the average levels of BMI index,TC,TG,FPG and HbA1c in the obese group were higher than those in the normal group,the differences were statistically significant(P<0.05).Conclusion:The incidence of precocious puberty in obese children is high,and the metabolic indexes of blood glucose and blood lipids in normal children,obese children and precocious children show an increasing trend,which shows that the increase of blood glucose and blood lipids can promote precocious puberty in children.