摘要
我国肺结核疫情十分严峻,临床上确诊活动性肺结核的"金标准"是结核分枝杆菌病原学检查,但对病原学阴性肺结核活动性的判断存在困难。作者介绍了目前用于病原学阴性肺结核活动性判断的实验室评价指标,包括结核分枝杆菌抗原、炎性和急性期反应标志物、免疫学指标、血液转录标志物等,指出了目前实验室检测技术在肺结核活动性判断及临床应用中存在的问题,并对其未来发展进行了论述与展望。
The epidemic situation of pulmonary tuberculosis in China is challenging.The pathogenic test of Mycobacterium tuberculosis is the"golden indicator"for the diagnosis of pulmonary tuberculosis,but the diagnosis becomes difficult when the test results are negative.This review introduces the current evaluation methods of laboratory tests for activity judgment of pulmonary tuberculosis,such as Mycobacterium tuberculosis antigens,inflammatory and acute-phase reaction markers,immunological indicators,and blood transcription markers;points out the problems of current laboratory tests for activity judgment and clinical implementation;and discusses its future development.
作者
付亮
邓国防
FU Liang;DENG Guo-fang(The Second Department of Lung,Shenzhen Third People’s Hospital,National Clinical Research Center for Infection Disease,Southern University of Science and Technology,Shenzhen 518112,China)
出处
《中国防痨杂志》
CAS
CSCD
2020年第6期626-629,共4页
Chinese Journal of Antituberculosis
基金
“十三五”国家科技重大专项(2018ZX10715004-002-012)。
关键词
结核
肺
活动性判断
实验室技术和方法
综述文献(主题)
Tubcrculosis,pulmonary
Activity judgment
Laboratory techniques and methods
Review literature as topic
