基于中医“阴阳自和”理论探讨自噬在骨质疏松症中的作用

Discussion on the effects of autophagy in osteoporosis based on“harmony of yin and yang”theory in traditional Chinese medicine

骨质疏松症(osteoporosis,OP)是以骨量减少和骨微结构退化为特征的全身性骨骼疾病,属于中医“骨痿”的范畴。自噬是真核细胞清除受损细胞成分或老化蛋白质的过程,属于细胞的一种自我保护机制,在调节骨稳态中发挥重要作用。自噬清除和代谢的过程,与中医“阴阳自和”相互为用、相互制约,有着极其相似的内涵。本文将从“阴阳自和”角度探讨自噬与OP之间的关系,进而丰富OP发病机制的理论内涵,为防治OP提供一些新的思路。

Osteoporosis(OP)is a systemic skeletal disease characterized by bone loss and bone microstructure degeneration,which belongs to the category of“bone wilting”in Chinese medicine.Autophagy is a process in which eukaryotic cells remove damaged cell components or aging proteins.It’s a self-protection mechanism of cells and plays a vital role in regulating bone homeostasis.The process of autophagy metabolism is similar to the interaction and mutual restriction in harmony of yin and yang.We tried to explore the relationship between autophagy and OP from the perspective of harmony of Yin and Yang,so as to enrich the theoretical connotation of OP pathogenesis and provide some new ideas for the prevention and treatment of OP.