前列地尔与疏血通注射液共同治疗急性脑梗塞患者的临床探讨

Clinical Study of Alprostadil and Shuxuetong Injection in the Treatment of Patients with Acute Cerebral Infarction

目的研究前列地尔与疏血通注射液共同治疗急性脑梗塞患者的临床效果。方法从该院方便选择156例急性脑梗塞患者作为研究对象,患者均于2018年6月-2019年8月来该院治疗,随机将其划分为对照组、研究组,各78例。对照组单一的采用疏血通注射液,研究组在对照组的基础上加入前列地尔展开治疗,对比两组的治疗效果。结果治疗前,两组之间的神经功能缺损评分数据差异无统计学意义(t=0.756,P=0.225>0.05);治疗后,研究组神经功能缺损评分为(5.8±1.5)分,对照组为(12.1±2.3)分,研究组明显低于对照组(t=20.263,P=0.000<0.05)。治疗前,两组患者的血液流变学指标差异无统计学意义(P>0.05);治疗后,两组患者的各个血液流变学指标明显低于治疗前,观察组明显低于对照组(P<0.05);对照组不良反应的发生率为7.7%,研究组为0.0%,研究组明显低于对照组(χ^2=4.333,P=0.037<0.05)。结论临床在治疗急性脑梗塞患者疾病过程中采用前列地尔与疏血通注射液联合治疗,临床取得效果良好,患者的神经功能得到明显的改善。

Objective To study the clinical effect of alprostadil and Shuxuetong injection in the treatment of patients with acute cerebral infarction.Methods From the hospital,156 patients with acute cerebral infarction were convenient selected as the research object.All patients were treated in the hospital from June 2018 to August 2019.They were randomly divided into control group and study group,78 cases each.The control group was treated with Shuxuetong injection alone.The research group was treated with alprostadil on the basis of the control group.The therapeutic effects of the two groups were compared.Results There was no statistically significant difference in neurological deficit score data between the two groups before treatment(t=0.756,P=0.225>0.05);after treatment,the neurological deficit score in the study group was(5.8±1.5)points,and the control group was(12.1±2.3)points.The study group was significantly lower than the control group at(t=20.263,P=0.000<0.05).Before treatment,there was no statistically significant difference in hemorheology parameters between the two groups of patients(P>0.05);after treatment,the individual hemorheology parameters of the two groups of patients were significantly lower than before treatment,and the observation group was significantly lower than the control group(P<0.05);the incidence of adverse reactions in the control group was 7.7%,the study group was 0.0%,the study group was significantly lower than the control group(χ^2=4.333,P=0.037<0.05).Conclusion The clinical application of alprostadil and Shuxuetong injection in the treatment of patients with acute cerebral infarction has achieved good clinical results,and the neurological function of the patients has been significantly improved.