中医药防治肝纤维化机制的研究进展

Research progress on prevention and treatment of liver fibrosis by traditional Chinese medicine

肝纤维化是由多种病因导致肝内结缔组织异常增生的病理生理过程,其发病机制复杂,目前尚无有效的治疗方法预防或减缓肝纤维化的进程。近年来研究发现中医药干预肝纤维化的进程有着独特疗效,中药通过抑制肝星状细胞活化、调控脂肪细胞因子、减轻肝脏炎性反应、改善氧化应激、抑制肝窦内皮细胞毛细血管化等方式拮抗肝纤维化;针灸可以改善机体免疫功能,改善肝脏功能状态,阻断肝纤维化进展。本文将中医药对肝纤维化发病机制的相关影响进行综述。

Liver fibrosis is a pathophysiological process of abnormal hyperplasia of intrahepatic connective tissue caused by a variety of causes.Its pathogenesis is complex,and there is no effective treatment to prevent or slow down the process of liver fibrosis.In recent years,studies have found that traditional Chinese medicine has a unique therapeutic effect on the process of liver fibrosis.Traditional Chinese medicine antagonizes liver fibrosis by inhibiting the activation of hepatic stellate cells,regulating adipocytokines,alleviating liver inflammatory response,improving oxidative stress,inhibiting the capillarization of sinusoidal endothelial cells,etc.;acupuncture and moxibustion can improve the immune function of the body,improve the state of liver function,and block liver fibrosis progress of liver fibrosis.This paper reviews the effects of traditional Chinese medicine on the pathogenesis of liver fibrosis.