宫颈癌患者组织β-catenin、Wnt1表达及与新辅助化疗疗效的关系

Expressions of β-catenin and Wnt1 in cervical cancer patients and their relationship with the efficacy of neoadjuvant chemotherapy

目的探讨宫颈癌患者组织β-连环蛋白(β-catenin)、Wnt1表达及与新辅助化疗疗效的关系。方法选取2015年10月至2019年10月本院116例宫颈癌患者作为研究组,选取95例良性子宫肌瘤患者作为对照组。比较两组组织β-catenin、Wnt1表达情况及研究组不同临床病理特征、化疗疗效组织β-catenin、Wnt1表达情况,并分析其与临床病理特征及新辅助化疗疗效关系。结果研究组组织β-catenin、Wnt1表达高于对照组,差异有统计学意义(P<0.05);研究组不同肿瘤直径、淋巴结转移、组织分化、FIGO分期患者β-catenin、Wnt1表达比较,差异有统计学意义(P<0.05);研究组组织β-catenin、Wnt1表达与肿瘤直径、淋巴结转移、FIGO分期呈正相关,与组织分化呈负相关(P<0.05);化疗后研究组CR患者β-catenin、Wnt1表达低于PR、SD、PD患者(P<0.05);Logistic分析显示,β-catenin、Wnt1与新辅助化疗疗效有关(P<0.05)。结论宫颈癌患者组织β-catenin、Wnt1呈高表达,其表达情况与临床病理特征、新辅助化疗疗效密切相关,有利于宫颈癌早期鉴别诊断及指导临床治疗。

Objective To explore the expression ofβ-catenin and Wnt1 in patients with cervical cancer and their relationship with the efficacy of neoadjuvant chemotherapy.Methods From October 2015 to October 2019,116 patients with cervical cancer in our hospital were selected as the study group,and 95 patients with benign uterine fibroids were selected as the control group.The expressions ofβ-catenin and Wnt1 in the two groups were compared with the clinical and pathological characteristics of the study group and the expression ofβ-catenin and Wnt1 in the chemotherapy efficacy group,and their relationship with the clinicopathological characteristics and the efficacy of neoadjuvant chemotherapy were analyzed.Results The expressions ofβ-catenin and Wnt1 in the study group were higher than those in the control group,the difference was statistically significant(P<0.05).The expressions ofβ-catenin and Wnt1 in patients with different tumor diameters,lymph node metastasis,tissue differentiation,FIGO staging,and parauterine infiltration were compared in the study group,and the differences were statistically significant(P<0.05).The expressions ofβ-catenin and Wnt1 in the study group were positively correlated with tumor diameter,lymph node metastasis,FIGO stage,and parauterine infiltration,and negatively correlated with tissue differentiation(P<0.05).The expressions ofβ-catenin and Wnt1 in CR patients in the study group after chemotherapy were lower than those in PR,SD,and PD patients(P<0.05).Logistic analysis showed thatβ-catenin and Wnt1 were related to the efficacy of neoadjuvant chemotherapy(P<0.05).Conclusionβ-catenin and Wnt1 are highly expressed in patients with cervical cancer,the expression ofβ-catenin and Wnt1 is closely related to the clinicopathological characteristics and the efficacy of neoadjuvant chemotherapy,which is beneficial to the early differential diagnosis of cervical cancer and to guide clinical treatment.