恩必普治疗对ICVD患者血液流变学、血清chemerin和Hcy水平的影响

Effects of Butylphthalide on hemorheology,levels of serum chemerin and Hcy in ICVD patients

目的观察恩必普治疗对缺血性脑血管疾病(ICVD)患者血液流变学、血清趋化素(chemerin)及同型半胱氨酸(Hcy)水平的影响。方法选取本院收治的72例ICVD患者,利用数字表法随机分为2组,各36例,对照组接受常规治疗,实验组于其基础上加用恩必普,比较2组治疗前后血液流变学[红细胞聚集指数、纤维蛋白原(FBG)、血浆黏度(PV)、低切全血粘度(nbl)与高切全血粘度(nbh)]、血清chemerin与Hcy水平、美国国立卫生研究院卒中量表(NIHSS)评分、日常生活能力(Barthel)变化及不良反应发生率。结果实验组治疗后红细胞沉降率、FBG、PV、nbl、nbh明显低于对照组(P<0.05);实验组治疗后血清chemerin与Hcy水平显著低于对照组(P<0.05);实验组治疗后NIHSS评分显著低于对照组(P<0.05),Barthel评分显著高于对照组(P<0.05);2组不良反应总发生率比较无显著差异(P>0.05)。结论恩必普可有效改善ICVD患者血液流变学、chemerin与Hcy表达情况,疗效显著,且具有较高安全性。

Objective To observe effects of Butylphthalide on hemorheology,levels of serum cheminin and homocysteine(Hcy)in patients with ischemic ceebral vascular disease(ICVD).Methods Seventy-two ICVD patients who were admitted to the hospital were divided into two groups by random number table method,36 cases in each group.The control group was given routine treatment,while experimental group was given Butylphthalide on basis of control group.The hemorheology[erythrocyte aggregation index,fibrinogen(FBG),plasma viscosity(PV),low cut whole blood viscosity(nbl),high cut whole blood viscosity(nbh)],levesl of serum chemerin and Hcy,changes in scores of National Institute of Health stroke scale(NIHSS)and Activities of Daily Living(Barthel),and incidence of adverse reactions before and after treatment were compared between the two groups.Results After treatment,erythrocyte sedimentation rate,FBG,PV,nbl and nbh in both groups were significantly decreased And the above indexes in experimental group were significantly lower than those in control group(P<0.05).After treatment,levels of serum chemerin and Hcy in both groups were significantly decreased.And the above indexes in experimental group were significantly lower than those in control group(P<0.05).After treatment,NIHSS scores in both groups were significantly decreased,while Barthel scores were significantly increased(P<0.05).NIHSS score of experimental group was significantly lower than that of control group,while Barthel score was significantly higher than that of control group(P<0.05).There was no significant difference in overall incidence of adverse reactions between the two groups(P>0.05).Conclusion Butylphthalide can effectively improve hemorrheology,expression of chemerin and Hcy in ICVD patients,with significant curative effect and high safety.