加味桑葚汤治疗卵巢早衰30例

Thirty Cases of Premature Ovarian Failure Treated with Supplemented Fructus Mori Decoction

目的:观察加味桑葚汤治疗卵巢早衰(premature ovarian failure,POF)的临床疗效。方法:将60例POF患者按照随机数字表法分为对照组和治疗组,每组各30例。对照组口服克龄蒙治疗,治疗组给予加味桑葚汤治疗。检测两组患者治疗前后血清激素水平[雌二醇(Estradiol,E2)、促黄体素(luteinizing hormone,LH)、促卵泡激素(follicle stimulating hormone,FSH)],比较两组患者的月经复潮率及治疗前后中医证候评分变化情况。结果:对照组有效率为66.67%,治疗组有效率为86.67%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后中医证候积分低于本组治疗前,且治疗组低于对照组,差异均有统计学意义(P<0.05)。两组患者治疗后FSH、LH水平低于治疗前,E2水平高于治疗前,治疗组治疗后FSH、LH水平低于对照组治疗后,E2水平高于对照组治疗后,差异均有统计学意义(P<0.05)。两组患者治疗后月经来潮例数高于本组治疗前,差异具有统计学意义(P<0.05),而两组患者月经复潮率比较,差异无统计学意义(P>0.05)。结论:加味桑葚汤治疗卵巢早衰,能有效改善患者临床症状、调节血清激素水平,对月经复潮具有促进作用。

Objective:To observe the clinical curative effect of Supplemented Fructus Mori Decoction on premature ovarian failure(POF).Methods:A total of 60 POF patients were divided into the control group and the treatment group according to the random number table method,with 30 cases in each group.The control group was treated with Climen for oral administration,and the treatment group was treated with Supplemented Fructus Mori Decoction.Serum hormone levels,including Estradiol(E2),luteinizing hormone(LH),follicle stimulating hormone(FSH),were measured before and after the treatment in the two groups.The menstrual recovery rate and the changes of TCM syndrome score before and after the treatment in the two groups were compared.Results:The effective rate was 66.67%in the control group and 86.67%in the treatment group,and the difference was statistically significant(P<0.05).After the treatment,the score of TCM syndrome in either of the two groups were lower than that in the same group before treatment,and the treatment group was lower than the control group,and all the differences were statistically significant(P<0.05).After the treatment,the levels of FSH and LH in the two groups were lower than those before the treatment,and the level of E2 in the treatment group was higher than that before the treatment.After treatment,the levels of FSH and LH in the treatment group were lower than those in the control group,and the level of E2 was higher than that in the control group,and all the differences were statistically significant(P<0.05).The number of menstrual recovery cases in the two groups after the treatment was higher than that before the treatment,the difference was statistically significant(P<0.05),but there was no significant difference in the menstrual recovery between the two groups(P>0.05).Conclusion:In terms of treating POF,Supplemented Fructus Mori Decoction can effectively improve the clinical symptoms of patients,regulate the level of serum hormone,and promote menstrual recovery.