补肾助阳针刺法治疗中风后失眠的疗效及对患者血清SP、NPY水平的影响

Therapeutic Effect of Acupuncture for Tonifying Kidney and Helping Yang on Insomnia After Apoplexy and its Influence on Serum SP and NPY Levels

目的:观察补肾助阳针刺法治疗中风后失眠的疗效及对患者血清P物质(substance P,SP)和神经肽Y(neuropeptide Y,NPY)水平的影响。方法:选取2018年1月至2019年2月本院全科门诊治疗的中风后失眠患者76例,按照随机数字表法分为治疗组和对照组,每组38例。对照组在中风常规治疗基础上给予艾司唑仑片口服治疗,治疗组在对照组治疗基础上给予补肾助阳针刺法治疗。结果:治疗组有效率为92.1%,对照组有效率为73.7%,治疗组高于对照组,差异有统计学意义(P<0.05);两组治疗后入睡困难、多梦易醒、晨起困难、心悸易惊积分均低于治疗前,且治疗组低于对照组,差异有统计学意义(P<0.05);两组治疗后PSQI评分、SRSS评分均低于治疗前,且治疗组低于对照组,差异有统计学意义(P<0.05);治疗组治疗后血清SP水平低于对照组,NPY水平高于对照组,差异有统计学意义(P<0.05)。结论:补肾助阳针刺法能够调节中风后失眠患者血清SP、NPY表达,提高患者睡眠质量,缓解临床症状。

Objective:To observe the therapeutic effect of acupuncture for tonifying kidney and helping yang on insomnia after apoplexy and its influence on serum substance P(SP)and neuropeptide Y(NPY)levels.Methods:A total of 76 patients with insomnia after apoplexy treated in the general outpatient department of our hospital from January 2018 to February 2019 were divided into the treatment group and the control group according to the random number table method,with 38 cases in each group.The control group was treated with Estazolam Tablet on the basis of routine treatment of stroke,and the treatment group was treated with acupuncture method of tonifying kidney and helping yang on the basis of treatment of the control group.Results:The effective rate was 92.1%in the treatment group and 73.7%in the control group.The difference was statistically significant(P<0.05).After the treatment,the scores of difficulty in falling asleep,being easy to wake up with dreams,difficult to get up in the morning and easy to be frightened with palpitation in the two groups were lower than those before the treatment,and all the differences between the two groups were statistically significant(P<0.05).After the treatment,PSQI score and SRSS score of the two groups were lower than those before the treatment,and all the differences were statistically significant(P<0.05).After the treatment,the SP level of the treatment group was lower than that of the control group,while the NPY level was higher than that of the control group,and all the differences were statistically significant(P<0.05).Conclusion:Acupuncture for tonifying the kidney and helping yang can regulate the expression of SP and NPY in serum of insomnia patients after apoplexy,improve the quality of sleep and relieve clinical symptoms.