粒子植入治疗联合CT引导下微波消融治疗中晚期肺癌及肺转移瘤的临床分析

Safety and Effectiveness Analysis of Percutaneous Microwave Thermal Ablation Therapy Combined Brachytherapy for Lung Malignant Lesion

背景与目的粒子植入治疗及微波消融治疗是无法手术的中晚期肺癌及肺转移瘤患者的一种可行治疗方式,然而两种治疗方式联合应用的治疗效果及安全性报道较少,本研究评估粒子植入治疗联合计算机断层扫描(computed tomography,CT)引导下经皮穿刺微波消融治疗中晚期肺癌及肺转移瘤的临床效果及安全性。方法回顾性分析本中心2018年5月-2018年12月接收的21例中晚期肺癌及肺转移瘤患者的临床资料,按照临床治疗方案分为两组,其中行粒子植入治疗的作为对照组,将粒子植入治疗联合CT引导下微波消融治疗的作为实验组,比较两组的患者的近期疗效及操作的安全性。结果实验组的有效率为28.57%,对照组的有效率为14.28%,两组患者不良反应发生率差异无显著性(P>0.05)。结论粒子植入治疗联合CT引导下经皮穿刺微波消融治疗中晚期肺癌及肺转移瘤的安全性可靠,近期疗效尚可。

Background and objective Microwave ablation and radioactive seed implantation are therapeutic op-tions for patients with advanced lung cancer and lung metastases lesion who are not surgical candidates.However,reports on therapeutic effectiveness and safety of the two combination treatments methods have been limited to small case series.This research was to assess the clinical outcome and safety of radioactive seed implantation combined with computed tomography(CT)-guided microwave ablation for the treatment of advanced lung cancer and lung metastases lesion.Methods The clinical data of 21 advanced lung cancer and lung metastases patients who received treatment at author hospital during the period from May 2018 to December 2018 were retrospectively analyzed.The patients were divided into two groups by whether received extra percutaneous microwave thermal ablation therapy.The short-term effectiveness and safety were analyzed.Results The ef-ficacy of control group was 28.75%,and the efficacy of experiment group was 14.28%.The rate of adverse reaction between two groups has no significantly difference(P>0.05).Conclusion Seed implantation combined with CT-guided microwave ablation for advanced lung cancer and lung metastases is safety and effective.