吉林市区生活方式、环境因素与帕金森病发病的相关因素分析

Analysis of the relationship between life style,environmental factors and the incidence of Parkinson’s disease in Jilin City

目的探讨不同临床分型帕金森病(PD)患者的影响因素,为PD的病因学研究提供更为可靠而丰富的临床资料,为今后开展PD的预防、有效治疗提供理论依据。方法采用病例对照研究的方法,选取2017年12月-2019年12月北华大学附属医院、吉林医药学院附属医院、吉林市中心医院确诊的PD患者177例,调查患者的年龄、性别、吸烟史、饮酒史、高血压病史、糖尿病病史、高尿酸血症病史、高同型半胱氨酸血症病史等。结果震颤型99例、运动迟缓型76例。震颤型、运动迟缓型PD患者年龄比较,差异无统计学意义(P>0.05)。不同吸烟史、饮酒史PD患者临床分型比较,差异无统计学意义(P>0.05)。高血压病史、糖尿病史与PD患者临床分型比较,差异无统计学意义(P>0.05)。高尿酸血症病史、高同型半胱氨酸血症病史与PD患者临床分型比较,差异无统计学意义(P>0.05)。结论PD患者以运动迟缓型发病较多。各相关因素与PD不同临床类型无明显关系。

Objective To explore the influencing factors of different clinical types of Parkinson s disease(PD),so as to provide more reliable and rich clinical data for the etiological study of PD,and provide theoretical basis for the prevention and effective treatment of PD in the future.Methods Using case-control study method,177 PD patients were selected from the Affiliated Hospital of Beihua University,Affiliated Hospital of Jilin Medical College and Central Hospital of Jilin from December 2017 to December 2019.The age,gender,smoking history,drinking history,hypertension history,diabetes history,hyperuricemia history,hyperhomocysteinemia history of the patients were investigated.Results Ninety-nine cases of tremor type and 76 cases of bradykinesia type.There was no significant difference in age between tremor PD and bradykinesia PD(P>0.05).There was no significant difference in clinical classification of PD patients with different smoking and drinking history(P>0.05).There was no significant difference in clinical classification between patients with hypertension,diabetes and PD(P>0.05).There was no significant difference in clinical classification between patients with hyperuricemia and PD(P>0.05).Conclusion Patients with PD are more likely to develop bradycardia.There was no significant relationship between the related factors and different clinical types of PD.