长链非编码RNA调控动物脂肪沉积研究进展与趋势

Progress and Tendency in the Regulation of Animal Fat Deposition by Long Non-coding RNA

长链非编码RNA(long non-coding RNA, lncRNA)是一类长度大于200个核苷酸,具有调控细胞增殖、分化、凋亡及自噬等多种生物学过程的非编码RNA分子。动物脂肪沉积是一个复杂而精密的程序化生物过程,受功能基因、非编码RNA和成脂相关信号通路等系列遗传因子的级联调控,其中长链非编码RNA因其重要的调控作用,近年来受到了越来越多研究的关注。该文从lncRNA生物学特性,转录水平、转录后水平和表观遗传水平等方面综述lncRNA对动物白脂沉积及棕脂产热调控的最新研究进展,以期为家畜肉品质改良提供理论依据。

Long non-coding RNA is a non-coding RNA molecule of more than 200 nucleotides in length that regulates various biological processes such as cell proliferation, differentiation, apoptosis and autophagy. The fat deposition process is regulated by a series of factors such as functional genes, non-coding RNAs and adipogenesis signaling pathways. In recent years, lncRNA has received more and more attention due to its important regulatory role. In this paper, the recent research progress of lncRNA on animal fat deposition regulation and thermogenesis from the biological characteristics of lncRNA, transcription level, post-transcriptional level and epigenetic level were reviewed to provide theoretical basis for the improvement of livestock meat quality.