胶态次枸橼酸铋钾与奥美拉唑联合抗生素治疗儿童消化性溃疡的疗效及安全性比较

Efficacy and Safety of Colloidal Bismuth Potassium Subcitrate and Omeprazole Combined with Antibiotics in the Treatment of Children with Peptic Ulcer

目的比较胶态次枸橼酸铋钾与奥美拉唑联合抗生素治疗儿童消化性溃疡(PU)的疗效及安全性。方法按随机数字表法将62例消化性溃疡患儿分为研究组和对照组,各31例。对照组患儿予以胶态次枸橼酸铋钾+抗生素治疗,研究组患儿予以奥美拉唑+抗生素治疗,两组患儿均治疗3周。结果研究组患儿治疗总有效率、幽门螺杆菌(HP)根除率均显著高于对照组(P <0. 05),腹痛、灼烧感、反酸等症状消失时间均显著短于对照组(P <0. 05)。治疗3周后,两组患儿的腹痛、灼烧感、反酸等临床症状评分及血清过氧化脂质(LPO)、丙二醛(MDA)水平均较治疗前显著降低,且研究组显著低于对照组(P <0. 05);一氧化氮(NO)、超氧化物歧化酶(SOD)水平则均较治疗前显著升高,且研究组显著高于对照组(P <0. 05)。研究组患儿不良反应发生率(9. 68%)与对照组(6. 45%)相当(P> 0. 05)。结论奥美拉唑联合抗生素治疗儿童PU的疗效优于胶态次枸橼酸铋钾联合抗生素,更有利于患儿临床症状的改善,且一定程度上减轻了氧化应激反应,利于病情转归,安全性均较高。

Objective To compare the efficacy and safety of colloidal bismuth potassium subcitrate and omeprazole combined with antibiotics for children with peptic ulcer(PU).Methods A total of 62 cases of children with PU were divided into the study group and control group according to the random number table method,31 cases in each group.The control group was treated with colloidal bismuth potassium subcitrate and antibiotics,and the study group was given omeprazole and antibiotics.Both groups were treated for 3 weeks.Results The total effective rate and helicobacter pylori(HP)eradication rate in the study group were significantly higher than those in the control group(P<0.05),and the disappearance times of abdominal pain,burning sensation and acid regurgitation were significantly shorter than those in the control group(P<0.05).After 3 weeks of treatment,the clinical symptoms scores of abdominal pain,burning sensation and acid regurgitation,and the serum levels of lipid peroxidase(LPO)and malondialdehyde(MDA)in two groups were significantly lower than those before treatment,and the scores and levels in the study group were significantly lower than those in the control group(P<0.05);the levels of nitric oxide(NO)and superoxide dismutase(SOD)were significantly higher than those before treatment,and the levels in the study group were significantly higher than those in the control group(P<0.05).There was no significant difference in the incidence rate of adverse reactions between the study group and the control group(9.68%vs.6.45%,P>0.05).Conclusion Omeprazole combined with antibiotics for PU can have better efficacy than colloidal bismuth potassium subcitrate combined with antibiotics.It can not only be more conducive to the improvement of clinical symptoms,but also reduce the oxidative stress response to a certain extent,and it is favorable for the prognosis of the disease with higher safety.