绝经后女性骨密度与血红蛋白、白蛋白及血尿酸的相关性分析

Correlation between bone mineral density and levels of hemoglobin and serum albumin and uric acid in postmenopausal women

目的 分析绝经后女性骨密度与血红蛋白、白蛋白及血尿酸的相关性.方法 495例绝经后妇女根据骨密度T值分为非骨质疏松(NOP)组和骨质疏松(OP)组,分析两组间血红蛋白、白蛋白及血尿酸水平与腰椎、股骨颈骨密度相关性.结果 校正年龄、绝经年限和BMI后,血红蛋白与腰椎3-4、左股骨颈、Ward三角及大粗隆骨密度相关(P<0.05);白蛋白仅与大粗隆骨密度相关(P<0.05);尿酸与腰椎2-4骨密度相关(P<0.05).回归分析示血红蛋白是影响腰椎3-4、股骨颈、Ward三角和大粗隆骨密度的独立因素(P<0.05);血尿酸是影响腰椎2-4骨密度的独立因素(P<0.01或0.05);白蛋白对腰椎、股骨颈骨密度均无影响(P>0.05).结论 血红蛋白、血尿酸分别是绝经后女性骨密度、腰椎骨密度的独立保护因素.

Objective To investigate the correlation between bone mineral density(BMD) and levels of hemoglobin and serum albumin and uric acid in postmenopausal women. Methods A total of 495 postmenopausal women were divided into non-osteoporosis group(n=186) and osteoporosis group(n=309) according to the T score. The relationship between lumbar and femoral neck BMD and levels of hemoglobin and serum albumin and uric acid in two groups were analyzed. Results After adjusting for age, menopausal duration and BMI, hemoglobin was correlated with BMD in L3-4, left femoral neck, Ward’s triangle and greater trochanter(P<0.05);serum albumin was only associated with BMD in greater trochanter(P<0.05);and serum uric acid was related to BMD in L2-4(P<0.05). Liner regression analysis show that hemoglobin was an independent factor for BMD in L3-4, femoral neck, Ward’s triangle and greater trochanter;serum uric acid was an independent factor for BMD in L2-4;and serum albumin had no impact on lumbar and femoral neck BMD. Conclusion Hemoglobin and serum uric acid may be independent protective factors for BMD and lumbar BMD in postmenopausal women.