替硝唑联合地塞米松预防阻生齿拔除术后并发症的临床观察

Clinical observation of the effect of tinidazole combined with dexamethasone in the prevention of complications after extraction of impacted teeth

目的 观察替硝唑+地塞米松对下颌阻生齿拔除术后并发症的预防效果.方法 92例下颌阻生齿拔除术患者随机分为对照组(46例,术后置入明胶海绵)和实验组(46例,在对照组基础上加予替硝唑联合地塞米松治疗).治疗3d后,对比两组张口受限评分、VAS评分、龈沟炎症因子指标、疼痛症状消失时间、创口愈合时间、并发症发生率.结果 治疗3d后,两组张口受限评分和VAS评分均低于同组治疗前,且以实验组更为显著;两组TNF-a、IL-8和IL-6水平均高于同组治疗前,且以对照组更为显著;实验组疼痛症状消失时间、创口愈合时间比对照组短,并发症发生率比对照组低(均P<0.05或0.01).结论 替硝唑+地塞米松+明胶海绵可有效减轻下颌阻生齿拔除术患者术后张口受限、疼痛等症状,抑制炎症介质释放,降低并发症发生率.

Objective To analyze the effect of tinidazole combined with dexamethasone in the prevention of complications after extraction of impacted teeth. Methods A total of 92 cases receiving extraction of impacted mandibular teeth were randomly divided into two groups, 46 cases in each group. The Control Group was inserted with gelatin sponge after the operation while the Experimental Group was treated with tinidazole combined with dexamethasone on the basis of the treatment for the Control Group. After the treatment for three days, the two groups were compared in terms of restricted opening score, VAS score, gingival sulcus inflammation factor, pain symptom extinction time, wound healing time and the incidence of the complication. Results After the treatment for three days, the restricted opening score and VAS of both groups were all lower than those in the same group, and the Experimental Group showed a more significant change;the TNFa, IL-8 and IL-6 level of both groups were all higher than those in the same group, and the Experimental Group showed a more significant change;the Experimental Group had the pain symptom extinction time and wound healing time shorter than the Control Group and had the incidence Control Group(P<0.05 or 0.01). Conclusion Tinidazole and dexamethasone in combination with the gelatin sponge can effectively reduce the symptoms of restricted opening and pain, inhibit the release of inflammatory mediators, and reduce the incidence of complications in patients receiving mandibular impacted teeth extraction.