适应性免疫细胞在自身免疫性溶血性贫血发病机制中的研究进展

Advance of adaptive immune cells in pathogenesis of autoimmune hemolytic anemia

自身免疫性溶血性贫血(AIHA)是常见的由自身抗体介导的溶血性贫血。适应性免疫是机体获得性、抗原特异性、抗病原微生物感染的高效防御机制。适应性免疫细胞分为B淋巴细胞与T淋巴细胞,它们与AIHA的发病机制密切相关。本文综述了近年来有关适应性免疫细胞在AIHA发病机制中作用的研究进展。

Autoimmune hemolytic anemia(AIHA)is a common hemolytic anemia mediated by autoantibodies.Adaptive immunity is an efficient defense mechanism for organism acquisition,antigen specificity,and infection against pathogenic microorganisms.Adaptive immune cells are classified into two types,B lymphocytes and T lymphocytes,which are closely related to the pathogenesis of AIHA.This paper reviews the advance of the role of adaptive immune cells in the pathogenesis of AIHA in recent years.