蛋白芯片法多肿瘤标志物检测在健康体检人群中肿瘤筛查的意义

Significance of multi-tumor marker protein chip screening in healthy population

目的:探讨蛋白芯片法多肿瘤标志物检测在健康人群中肿瘤筛查的临床意义。方法:应用蛋白芯片法检测7339例健康体检者CEA、AFP、CA125、CA19-9、CK19、SCC、NSE、β-HCG、c-PSA、CA15-3、CA72-4和CA242;异常结果选用电化学发光仪复查,通过病理学和影像学等进一步明确诊断并进行患者随访。结果:7339例体检者中检测出肿瘤标志物异常者601例,阳性率为8.18%,196例单个肿瘤标志物复查阳性为151例,真阳性率为90.44%,其中13例在不同时间经病理学、影像学等检查确定为肿瘤,肿瘤检出率为0.2%。结论:蛋白芯片法检测多肿瘤标志物可以作为健康人群中肿瘤筛查的手段之一,可达到早期发现、早期治疗的目的。

Objective:To investigate the clinical significance of multi-tumor marker protein chip screening in healthy population.Methods:7339 healthy people were detected by protein chip for CEA,AFP,CA125,CA19-9,CK19,SCC,NSE,β-HCG,c-PSA,CA15-3,CA72-4 and CA242.CobasE601 electrochemiluminescent assay was used as the gold standard to re-examine the abnormal results of single-tumor markers,and results of the two methods were compared.Results:Among 7339 cases of physical examination,the results of 601 cases were found to be abnormal by protein chip method,a total positive rate was 8.18%.151 cases were found to be positive by single tumor marker re-examination,and the true positive rate was 90.44%.13 of them were confirmed as early or intermediate stage tumors by pathological and imaging examinations at different times,a detection rate of 0.2%.Conclusion:Multi-tumor markers protein chip technology is suitable for tumor screening in people′s health check-up.When the results are abnormal,regular review and follow-up should be carried out so as to better achieve the purpose of early detection and treatment.