α-烯醇化酶蛋白抗原的表达与血管相关疾病及肿瘤发生的关系

Relationship between expression ofα-enolase protein antigen and vascular diseases and tumorigenesis

α-烯醇化酶(ENO1)参与血管相关疾病的发生发展以及恶性肿瘤细胞的演变和转移,尤其在血管内皮的促炎激活、功能障碍以及自身免疫病微小血管的损害过程发挥重要作用。本文从4个方面分别综述:血管内皮细胞及相关免疫细胞表面的ENO1参与介导炎症活化,引发血管相关疾病;在低氧条件下,HIF-1α通过诱导ENO1表达参与血管生成;ENO1通过翻译后修饰参与血管相关疾病发生发展;ENO1作为毒性因子增加血管的通透性引起血管相关疾病。

α-enolase(EN01)is involved in development of vascular-related diseases and evolution and metastasis of malignant tumor cells,especially in proinflammatory activation,dysfunction of vascular endothelium and microvascular damage in autoimmune diseases.This article reviews from four aspects:ENO1 on surface of vascular endothelial cells and related immune cells is involved in mediating inflammatory activation,causing vascular-related diseases.Under hypoxic conditions,HIF-1αparticipates in angiogenesis by inducing expression of ENO1;ENO1 participates in development of vascular related diseases through post-translational modification and ENO1;As a toxic factor,ENO1 increases vascular permeability and causes vascular related diseases.