骨髓增生异常综合征患者红细胞参数水平变化及临床意义

Changes and clinical significance of red blood cell parameters in patients with myelodysplastic syndrome

目的探讨红细胞参数在骨髓增生异常综合征(MDS)患者中的水平变化及临床意义。方法选取2014年1月至2018年12月该院收治的90例MDS患者为MDS组,同时选取体检健康者90例为健康组。比较MDS组与健康组红细胞参数[血红蛋白(Hb)、平均红细胞体积(MCV)、平均红细胞血红蛋白含量(MCH)、平均血红蛋白浓度(MCHC)、红细胞分布宽度变异系数(RDW-CV)、红细胞分布宽度标准差(RDW-SD)]水平;比较MDS不同预后危险程度、不同病理分型患者红细胞参数水平;分析红细胞参数在MDS诊断、预后评估中的意义。结果MDS组MCV、MCH、RDW-CV、RDW-SD水平均高于健康组,Hb、MCHC水平均低于健康组,差异有统计学意义(P<0.05)。根据不同预后危险程度分组,MDS患者高危组Hb水平低于其余各组,差异有统计学意义(P<0.05);中危-1组MCV、MCH水平均高于低危组和中危-2组,差异有统计学意义(P<0.05);不同预后危险程度组间MCHC、RDW-CV及RDW-SD水平比较,差异均无统计学意义(P>0.05)。不同病理分型组红细胞参数水平比较,差异均无统计学意义(P>0.05)。结论红细胞参数水平对MDS的临床诊断及预后评估具有一定指导价值。

Objective To investigate the changes and clinical significance of red blood cell parameters in patients with myelodysplastic syndrome(MDS).Methods A total of 90 MDS patients admitted to the hospital from January 2014 to December 2018 were selected as the MDS group,and 90 healthy people underwent medical examination were selected as the healthy group.Red blood cell parameters,including hemoglobin(Hb),mean corpuscular volume(MCV),mean hemoglobin concentration(MCH),mean corpuscular hemoglobin concentration(MCHC),variation coefficient of red blood cell distribution width(RDW-CV),standard deviation of red blood cell distribution width(RDW-SD)were compared between the MDS group and the healthy group.The levels of red blood cell parameters in patients with different prognostic risks and pathological types of MDS were compared.The significance of red blood cell parameters in MDS diagnosis and prognosis assessment was analyzed.Results The levels of MCV,MCH,RDW-CV and RDW-SD in the MDS group were higher than those in the healthy group,and the levels of Hb and MCHC were lower than those in the healthy group,the differences were statistically significant(P<0.05).MDS patients were devided according to the different risk degree of prognosis,and the level of Hb in the high-risk group was lower than those in other groups,and the difference was statistically significant(P<0.05).The levels of MCV and MCH in the medium-risk-1 group were higher than those in the low-risk group and the medium-risk-2 group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the levels of MCHC,RDW-CV and RDW-SD among groups with different prognostic risks(P>0.05).There was no significant difference in red blood cell parameters between different pathological types groups(P>0.05).Conclusion The level of red blood cell parameters has a certain guiding value for the clinical diagnosis and prognosis evaluation of MDS.