摘要
原发性胆汁性胆管炎(PBC)原称原发性胆汁性肝硬化,是一种累及肝内胆管系统的慢性进展性自身免疫性疾病。PBC主要发生于女性,在过去几十年,PBC的发病率和患病率在全球呈上升趋势。而PBC患者早期常无临床症状,随着病情进展,最终发展为肝纤维化及肝硬化、肝细胞性肝癌而死亡。随着技术的革新及检测水平的提高,PBC研究取得了飞速发展。该文就PBC的流行病学、血清标志物及遗传学研究新进展进行综述。
Primary biliary cholangitis(PBC),formerly known as primary biliary cirrhosis,is a chronic progressive autoimmune disease involving the intrahepatic bile duct system.PBC occurs mainly in women,and its incidence and prevalence have been on the rise globally in the past few decades.Patients with PBC often have no clinical symptoms in the early stage,and eventually die as the disease progresses to liver fibrosis,cirrhosis and hepatocellular carcinoma.With the innovation of technology and the improvement of detection level,the research on PBC has made rapid development.This paper reviews the recent progress in the study of epidemiology,serum markers and genetics of PBC.
作者
李玉武
梁成通
安覃景(综述)
韩崇旭(审校)
LI Yuwu;LIANG Chengtong;AN Tanjing;HAN Chongxu(School of Postgraduate,Dalian Medical University,Dalian,Liaoning 116044,China;Department of Clinical Medical Examination,Northern Jiangsu People′s Hospital,Yangzhou,Jiangsu 225001,China)
出处
《国际检验医学杂志》
CAS
2020年第13期1636-1640,共5页
International Journal of Laboratory Medicine
基金
国家重点基础研究发展计划(973计划)(2015CB755400)
江苏省苏北人民医院院级扶持技术项目(fcjs201748)。