肥胖2型糖尿病患者神经肽Y水平与糖脂代谢的相关性分析

Analysis of the Correlation between Neuropeptide Y Level and Glycolipid Metabolism in Obese Type 2 Diabetic Patients

目的:探讨肥胖2型糖尿病患者神经肽Y(NPY)水平与糖脂代谢的相关性。方法:选择2017年7月至2019年7月我院接诊的134例肥胖2型糖尿病患者为本研究对象,设为观察组,并选择我院收治的2型糖尿病非肥胖患者100例作为对照组,分析腰围、腹围、臀围、BMI、腰臀比(WHR)、血清NPY、空腹血糖(FPG)、糖化血红蛋白(Hb Alc)、空腹胰岛素(FINS)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平变化情况,及其之间的相关性分析。结果:观察组腹围、腰围、臀围、腰臀比及BMI水平均显著高于对照组,差异显著(P<0.05);观察组患者血清NPY、FPG、Hb Alc水平显著高于对照组,FINS水平显著低于对照组,差异显著(P<0.05);观察组患者血清TC、TG、LDL-C水平显著高于对照组,HDL-C水平显著低于对照组,差异显著(P<0.05);将FPG、Hb Alc、FINS、TC、TG、LDL-C、HDL-C作为因变量,将血清NPY作为自变量,在相关性分析结果中显示,血清NPY和FPG、Hb Alc、TC、TG、LDL-C之间均呈正相关(r=0.399,0.173,0.435,0.451,0.376,P均<0.05),血清NPY和FINS、HDL-C之间均呈负相关(r=-0.566,-0.223,P均<0.05)。结论:在肥胖2型糖尿病患者中NPY水平显著升高,且与腹部脂肪增加、糖脂代谢显著相关。

Objective:To study Analysis of theCorrelation between neuropeptide Y level and glycolipid metabolism in obese type 2 diabetic patients.Methods:134 cases of obese type 2 diabetes patients admitted to our hospital from July 2017 to July 2019 were selected as the object of this study,which was set as the observation group,and 100 cases of non-obese type 2 diabetes patients admitted to our hospital were selected as the control group.Analysis,6,waist and hip circumference,BMI,waist hip ratio(WHR)and serum NPY,fasting plasma glucose(FPG),glycosylated hemoglobin(HbAlc),fasting insulin(FINS),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)level changes,and the correlation between the analysis.Results:The abdominal circumference,waist circumference,hip circumference,waist-hip ratio and BMI of the observation group were significantly higher than those of the control group,with significant differences(P<0.05).The serum NPY,FPG and HbAlc levels in the observation group were significantly higher than those in the control group,and the FINS levels were significantly lower than those in the control group,with significant differences(P<0.05).Serum levels of TC,TG and ldl-c in the observation group were significantly higher than those in the control group,and hdl-c levels were significantly lower than those in the control group,with significant differences(P<0.05).The FPG,HbAlc,FINS,TC,TG,LDL,HDL-C-C as dependent variable,the serum levels of NPY as independent variable,in the correlation analysis results showed that serum NPY and FPG,HbAlc,TC,TG,LDL-there was a positive correlation between C(r=0.399,0.173,0.435,0.451,0.376,P<0.05),serum NPY and are negatively correlated between FINS,HDL-C(r=0.566,0.223,P<0.05).Conclusion:NPY level was significantly increased in obese type 2 diabetic patients and was significantly correlated with glucose and lipid metabolism.