复方丹参滴丸对2型糖尿病合并动脉粥样硬化患者炎症及凝血功能的影响

Effect of compound danshen dripping pills on inflammation and blood coagulation in patients with type 2 diabetes mellitus with atherosclerosis

目的探讨复方丹参滴丸对2型糖尿病合并动脉粥样硬化患者炎症及凝血功能的影响。方法选择2017年1月至2018年12月在上海市宝山区大场医院治疗的86例2型糖尿病合并动脉粥样硬化患者为研究对象,按照随机数表法将患者分为对照组和观察组,每组43例。对照组使用阿司匹林肠溶片治疗,观察组在对照组治疗的基础上使用复方丹参滴丸治疗。治疗3个月,比较两组患者的凝血功能指标、炎症因子及不良反应发生情况。结果治疗后,观察组患者的活化部分凝血活酶时间(APTT)和凝血酶原时间(PT)分别为(26.37±1.91) s、(12.04±0.52) s,明显长于对照组的(23.48±1.51) s、(10.79±0.38) s,纤维蛋白原(Fib)水平为(3.36±0.73) g/L,明显低于对照组的(4.62±0.94) g/L,差异均有统计学意义(P<0.05),但两组患者的凝血酶时间(TT)比较差异无统计学意义(P>0.05);治疗后,观察组患者的血清高敏C反应蛋白(hs-CRP)和肿瘤坏死因子α(TNF-α)水平分别为(2.58±0.49) mg/L、(63.25±9.63) ng/L,明显低于对照组的(4.91±0.67) mg/L、(104.51±16.62) ng/L,差异均有统计学意义(P<0.05);观察组患者的不良反应发生率为11.63%,明显低于对照组的27.91%,差异有统计学意义(P<0.05)。结论复方丹参滴丸可有效降低2型糖尿病合并动脉粥样硬化患者的炎症因子,改善凝血功能,同时并发症发生率较低。

Objective To investigate the effects of compound danshen dripping pills on inflammation and blood coagulation in patients with type 2 diabetes mellitus complicated with atherosclerosis.Methods A total of 86 patients with type 2 diabetes mellitus with atherosclerosis treated in Dachang Hospital of Baoshan District of Shanghai from January 2017 to December 2018 were selected as the research subjects.According to the random number table method,they were randomly divided into control group and observation group,with 43 patients in each group.The control group was treated with aspirin enteric-coated tablets,and the observation group was treated with compound danshen dripping pills on the basis of the control group,for 3 months.The blood coagulation index,inflammatory factors,and adverse reaction rate were compared between the two groups.Results After treatment,the activated partial thromboplastin time(APTT)and prothrombin time(PT)in the observation group were(26.37±1.91)s,(12.04±0.52)s,respectivly,which were significantly higher than(23.48±1.51)s,(10.79±0.38)s in the control group,and the level of fibrinogen(Fib)was(3.36±0.73)g/L,which was significantly lower than(4.62±0.94)g/L in the control group(P<0.05).There were no significant difference in thrombin time(TT)between the two groups(P>0.05).After treatment,the levels of serum high-sensitivity C-reactive protein(hs-CRP)and tumor necrosis factor-α(TNF-α)in the observation group were(2.58±0.49)mg/L,(63.25±9.63)ng/L,which were significantly lower than(4.91±0.67)mg/L,(104.51±16.6)ng/L in the control group(P<0.05).The incidence of adverse reactions in the observation group was 11.63%,which was significantly lower than 27.91%in the control group(P<0.05).Conclusion Compound Danshen Dripping Pill can effectively reduce the level of inflammatory factors and improve blood coagulation in patients with type 2 diabetes mellitus and atherosclerosis,and the incidence of complications is low.