血清C肽、糖化血红蛋白与N-乙酰β-D-氨基葡糖苷酶联合检验在诊断2型糖尿病早期肾损伤中的应用

Application of combined test of serum C-peptide,glycosylated hemoglobin and N-acetylβ-D-glucosidase in the diagnosis of early renal injury of type 2 diabetes mellitus

目的探讨血清C肽、糖化血红蛋白与N-乙酰β-D-氨基葡糖苷酶联合检验在诊断2型糖尿病早期肾损伤中的应用。方法选择2018年1月~2019年6月我院收治的50例2型糖尿病早期肾损伤患者作为为研究组,另选取同时间段收治的50例单纯2型糖尿病患者作为对照1组,另选取同时间段来我院进行常规体检的50例自愿者作为对照2组。三组均接受血清C肽、糖化血红蛋白与N-乙酰β-D-氨基葡糖苷酶联合检验诊断,并进行比较分析。结果研究组的糖尿病病程长于对照1组,差异有统计学意义(P<0.05);研究组的空腹血糖、尿微量白蛋白/肌酐比值水平均高于对照1组、对照2组,差异有统计学意义(P<0.05);研究组的糖化血红蛋白、N-乙酰β-D-氨基葡糖苷酶水平均高于对照1组、对照2组,差异有统计学意义(P<0.05);研究组的血清C肽水平低于对照1组、对照2组,差异有统计学意义(P<0.05);对照1组的空腹血糖、尿微量白蛋白/肌酐比值水平均高于对照2组,差异有统计学意义(P<0.05);对照1组的糖化血红蛋白、N-乙酰β-D-氨基葡糖苷酶水平均高于对照2组,差异有统计学意义(P<0.05);对照1组的血清C肽水平低于对照2组,差异有统计学意义(P<0.05)。结论在临床检查诊断糖尿病早期肾损伤过程中,应用血清C肽、糖化血红蛋白与N-乙酰β-D-氨基葡糖苷酶联合检验方法可以起到有效作用,能够提供准确检查诊断参考依据,具有重要应用价值。

Objective To investigate the application of combined test of serum C peptide, glycosylated hemoglobin and N-acetyl β-D-glucosidase in the diagnosis of early renal injury in type 2 diabetes mellitus. Methods A total of 50 patients with early renal injury of type 2 diabetes mellitus treated in our hospital from January 2018 to June 2019 were selected as the study group. Another 50 patients with type 2 diabetes mellitus treated in our hospital in the same period of time were selected as the control group 1. In addition, 50 volunteers who came to the hospital for routine physical examination in the same time period were selected as the control group 2. All the three groups were diagnosed by combined test of serum C-peptide, glycosylated hemoglobin and N-acetyl β-D-glucosidase, and the results were compared and analyzed. Results The course of diabetes in the study group was longer than that in the control group 1, and the difference was statistically significant (P<0.05). The levels of fasting blood glucose and urinary microalbumin to creatinine in the study group were higher than those in the control group, and the differences were statistically significant (P<0.05). The levels of glycosylated hemoglobin and N-acetyl β-D-glucosidase in the study group were higher than those in the control group 1 and control group 2, and the differences were statistically significant (P<0.05). The levels of serum C-peptide in the study group was lower than that in the control group 1 and control group 2, the difference was statistically significant (P<0.05). The levels of fasting blood glucose and urinary microalbumin/creatine ratio in the control group 1 were higher than those in the control group 2, and the differences were statistically significant (P<0.05). The levels of of hemoglobin, N-acetyl β-D-glucosidase in the control group 1 were higher than those of the control group 2, and the difference was statistically significant (P<0.05). The level of serum C-peptide in the control group 1 was lower than that in control group 2, and the difference was statistically significant (P<0.05). Conclusion The combined test of serum C-peptide, glycosylated hemoglobin and N-acetyl β-D-glucosidase can play an effective role in the diagnosis of early diabetic renal injury. It can provide an accurate reference for the diagnosis of diabetes mellitus, and has important application value.