血清sTWEAK水平对冠状动脉病变程度的预测价值

Predictive value of sTWEAK levels for severity of coronary artery disease

目的探讨可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)水平对预测冠状动脉病变严重程度的临床价值。方法选取该院2019年1-8月收治的275例患者,冠心病(CHD)组215例,其中急性冠状动脉综合征(ACS)组120例,稳定性心绞痛(SAP)组95例。对照组为60例冠状动脉造影阴性患者。检测sTWEAK水平,对比分析sTWEAK水平在不同冠状动脉病变中的变化趋势。结果(1)ACS组、SAP组sTWEAK水平均较对照组升高,而ACS组较SAP组sTWEAK水平明显升高,差异均有统计学意义(P<0.05);(2)三支病变组、双支病变组、单支病变组sTWEAK水平均较对照组升高,三支病变组较双支病变组、单支病变组均显著升高,差异均有统计学意义(P<0.05);(3)轻度、中度、重度组sTWEAK水平较对照组升高,重度组较中度组、轻度组升高明显,差异均有统计学意义(P<0.05);(4)A型、B型、C型病变组sTWEAK水平均较对照组升高,C型组较B型组、A型组升高明显,差异均有统计学意义(P<0.05);(5)sTWEAK与肌钙蛋白I呈正相关(P<0.05)。结论sTWEAK与CHD的发生、发展密切相关,对CHD的诊断、判断严重程度及预后均有较高的临床价值。

Objective To explore the value of Soluble TNF-like weak inducer of apoptosis(sTWEAK)for prediction of coronary artery lesion severity.Methods A total of 275 patients selected and 215 in coronary heart disease(CHD)group including 120 in acute coronary syndrome group(ACS group)and 95 in stable angina pectoris group(SAP group),and 60 patients with negative coronary angiography in control group.The expression of sTWEAK was detected,which was observed in different coronary artery lesions.Results The expression of sTWEAK increased in ACS group and SAP group compared with control group,which was more significant in ACS group than that in SAP group(P<0.05).The expression of sTWEAK increased in vessel group,two vessel group,three vessel group compared with control group,which were more significant in three vessel group than those in two vessel group and single vessel group(P<0.05).The expression of sTWEAK increased in mild group、medium group,severe group compared with control group,which were more significant in severe group than those in medium group and mild group(P<0.05).The expression of sTWEAK increased in type A group,type B group,type C group compared with control group,which were more significant in type C group than those in type B group and type A group(P<0.05).sTWEAK was positively correlated to cardiac troponinⅠ(P<0.05).Conclusion sTWEAK is closely related to the occurrence and development of CHD,which has high clinical value in the diagnosis,judgment severity and prognosis of coronary heart disease.