C-反应蛋白及其基因多态性与缺血性脑卒中的研究进展

Research progress of C-reactive protein and its gene polymorphism on ischemic stroke

C-反应蛋白(CRP)作为一种急性炎症标志物,在动脉粥样硬化、组织损伤、凝血和血栓形成过程中起重要作用,具有检测快速、简便、费用低廉和敏感度高的优点,是缺血性脑卒中研究中重要的生物标志物.但CRP特异性差、受多种因素影响的属性限制了其在临床的应用价值.而CRP基因多态性具有稳定的属性,两者结合可以更好地应用于缺血性脑卒中研究领域,对脑卒中的诊断、病情评价和预后监测起重要作用.现就近年来CRP及其基因多态性与缺血性脑卒中的研究情况进行概述.

As an acute inflammatory marker,C-reactive protein(CRP)plays an important role in the process of atherosclerosis,tissue damage,coagulation and thrombosis.It is rapid and simple,and has the advantages of low cost and high sensitivity.It is an important biomarker in ischemic stroke research.However,its poor specificity and properties influenced by many factors limit its clinical application.CRP gene polymorphism has stable properties.The combination of CRP and its gene polymorphism can better serve the field of ischemic stroke,and play an important role in the diagnosis,disease evaluation and prognosis monitoring of stroke.In this paper,researches on CRP and its genetic polymorphism on ischemic stroke studies in recent years are summarized.