摘要
利用苯乙烯为模板成功制备了具有良好水溶性的聚乙二醇功能化中空介孔纳米硅球,利用红外光谱、热重、动态光散射及透射电镜对其进行表征.该载体对小檗碱的载药量及包载率高达136.4 mg/g和68.2%.体外研究结果显示,24 h累积释放率约43.2%,细胞存活率均在80%以上.体内代谢结果显示,纳米载体药物使血药浓度显著提高.
Polyethylene glycol functionalized hollow mesoporous silica nanoparticles(HMS-PEG)with good water solubility were successfully prepared using styrene as template,and characterized by infrared spectroscopy,thermogravimetry,dynamic light scattering and transmission electron microscopy.The drug loading rate and entrapment rate of berberine based on HMS-PEG were as high as 136.4 mg/g and 68.2%,respectively.The results of vitro showed that the cumulative release rate was about 43.2% within 24 h,and the cell survival rate was above 80%.The metabolism results in vivo showed that nano-carrier drugs significantly increased BBR concentration in mouse plasma.
作者
史艳梅
晁利芹
张茜
杨玉冬
李秀敏
苗明三
梅林
SHI Yanmei;CHAO Liqin;ZHANG Xi;YANG Yudong;LI Xiumin;MIAO Mingsan;MEI Lin(Academy of Traditional Chinese Medicine,Henan University of Chinese Medicine,Zhengzhou 450001,China;School of Material and Chemical Engineering,Zhongyuan University of Technology,Zhengzhou 450007,China;Department of Microbiology and Immunology,New York Medical College,New York 10595,USA)
出处
《信阳师范学院学报（自然科学版）》
CAS
北大核心
2020年第3期405-409,共5页
Journal of Xinyang Normal University(Natural Science Edition)
基金
国家自然科学基金项目(51703259)
河南省高等学校重点科研项目(18B360007)
河南中医药大学基金(03301232,00104358)。
关键词
小檗碱
中空介孔纳米硅球
药物缓释
生物利用度
berberine
hollow mesoporous silica nanoparticles
sustained drug release
bioavailability
