帕金森病生物节律紊乱的研究进展

Disruption of circadian rhythm in Parkinson′s disease

帕金森病是中老年人常见的神经性退行性疾病,证据表明帕金森病患者存在多种生物节律紊乱相关症状,但其机制以及病理生理过程仍不明确。生物节律受到体内外环境的共同调节,通过亮光疗法、褪黑素的应用对生物节律系统进行干预可能成为未来治疗帕金森病的潜在治疗手段。本文主要从帕金森病临床表现中生物节律相关参数异常变化的现象,到帕金森病生物节律可能的发生机制进行文献复习和综述,为进一步探索生物节律在帕金森病治疗中的意义提供依据。

Parkinson′s disease(PD)is the common progressive neurodegenerative disorder affecting older adults.Alterations of the circadian system occur in PD patients.However,the molecular mechanisms and pathophysiological process remain elusive.Circadian rhythm is modulated by both internal and external factors and using bright light and melatonin as chronotherapeutic tools may be potential therapies to improve symptoms of PD in the future.This article reviewed the abnormal changes of circadian parameters in clinical symptoms of PD and the possible mechanisms of circadian rhythm to provide basis for exploring the therapeutic strategies of circadian rhythm in PD.