血清淀粉样蛋白A与C-反应蛋白在小儿上呼吸道感染中的早期诊断价值

Early diagnostic value of serum amyloid A and C-reactive protein in children with upper respiratory tract infection

目的探讨血清淀粉样蛋白A(SAA)与C-反应蛋白(CRP)在小儿上呼吸道感染中的早期鉴别诊断价值。方法选取2018年10月-12月在本院就诊的急性上呼吸道感染患儿为研究对象,其中细菌感染组205例、病毒感染组102例、肺炎支原体感染组229例及对照组96例,检测血清SAA和CRP。结果 SAA在细菌感染组、病毒感染组和MP感染组的异常率分别为98. 54%、79. 41%、55. 02%;CRP则分别为73. 66%、10. 78%、28. 38%,差异有统计学意义(P <0. 05)。细菌感染组SAA和CRP水平明显高于其他组;病毒感染组和MP感染组SAA水平高于对照组;MP感染组CRP水平均高于病毒感染组和对照组,差异均有统计学意义(P <0. 05)。细菌感染组SAA和CRP的ROC曲线下面积分别为0. 987、0. 974;病毒感染组分别为0. 904、0. 703;MP感染组分别为0. 746、0. 666。结论联合检测SAA和CRP能够为小儿上呼吸道感染的鉴别诊断提供参考依据。

Objective To explore the early differential and diagnostic value of serum amyloid A(SAA)and C-reactive protein(CRP)in children with upper respiratory tract infection.Methods The children with acute upper respiratory tract infection who were treated in our hospital from October to December 2018 were selected as the subjects of study for the detection of SAA and CRP,including 205 patients in bacterial infection group,102 patients in viral infection group,229 patients in Mycoplasma pneumoniae infection group and 96 patients in control group.Results The abnormal rates of SAA in bacterial infection group,viral infection group and MP infection group were 98.54%,79.41%,55.02%,and that of CRP was 73.66%,10.78%and 28.38%,with the differences statistically significant(P<0.05).SAA and CRP levels in bacterial infection group were significantly higher than those in other groups;SAA levels in viral infection group and MP infection group were higher than those in control group;CRP levels in MP infection group were higher than those in viral infection group and control group,with the differences statistically significant(P<0.05).The ROC curves of SAA and CRP were 0.987 and 0.974 in bacterial infection group,0.904 and 0.703 in viral infection group and 0.746 and 0.666 in MP infection group.Conclusion The combined detection of SAA and CRP can provide reference for the differential diagnosis of upper respiratory tract infection in children.