血清铁蛋白在强直性脊柱炎诊治中的价值

The value of serum ferritin in the diagnosis and treatment of ankylosing spondylitis

目的探究血清铁蛋白在强直性脊柱炎(AS)中诊治和监测病情活动度的价值。方法收集本院85例AS患者为疾病组,另外同期收集在本院体检的82例健康者为对照组,依据Bath强直性脊柱炎病情活动指标(BASDAI)分为缓解期和活动期期,检测所有入选人员的血清铁蛋白(SFe)、人类白细胞抗原(HLA)-B27(HLA-B27)、C-反应蛋白(CRP)和红细胞沉降率(ESR)水平,并统计分析。结果 AS组患者血清铁蛋白水平显著高于对照组(P <0. 05),活动期的血清铁蛋白显著高于缓解期(P <0. 05)。血清铁蛋白的灵敏度和特异度分别为82. 1%和73. 4%,SFe与BASDAI、CRP和ESR均呈正相关(r值分别为0. 84、0. 76、0. 68,P <0. 05)。结论血清铁蛋白不但是AS诊断指标之一,而且也是监测AS患者疾病活动的重要指标。

Objective To investigate the value of serum ferritin in the diagnosis of ankylosing spondylitis( AS) and that of evaluating the disease activity. Methods Eighty five cases of hospitalized RS( they were divided into the treatment group activity and mitigation period to BASDAI) were collected;the other group were 82 cases of healthy controls. The levels of serum ferritin( SFe),C-reactive protein( CRP),erythrocyte sedimentation rate( ESR) and human leukocyte antigen B27( HLA-B27) were tested for statistical analysis. Results The serum SFe level of AS group was significantly higher than the control group( P < 0. 05). In active RS group,the level of SFe was higher than mitigation RS group( P < 0. 05). The sensitivity and specificity of SFe were 82. 1% and 73. 4%,respectively,and SFe was positively correlated with BASDAI,CRP and ESR( r =0. 84,r = 0. 76,r = 0. 68,P < 0. 05). Conclusion SFe can be used not only as one of the RS for its diagnosis,but also as an important index in assessing the disease activity.