p53和EGFR在大肠腺瘤及大肠癌组织中的表达及临床意义

Expression and clinical significance of p53 and EGFR in colorectal adenoma and colorectal cancer

目的探讨p53和EGFR在大肠腺瘤及大肠癌组织中的表达及临床意义。方法选取我院2017年1月~2018年12月收治的大肠癌、大肠腺瘤以及正常结肠粘膜患者各50例,对大肠癌、大肠腺瘤以及正常结肠粘膜组织中的p53、表皮生长因子(EGFR)进行检测,分析其与大肠癌临床病理指标的关系,探讨其在大肠癌发生发展中的作用及相互间的关系。结果大肠癌中p53和EGFR表达与Dukes分期相关,随着期数的升高,p53和EGFR表达阳性率也逐渐升高,p53和EGFR在患者体内的表达与大肠癌的癌变程度呈正相关。结论p53和EGFR的表达对肿瘤的浸润程度、转移程度、分化程度都有直接的影响,因此p53和EGFR的表达可以作为大肠腺瘤及大肠癌组织中的早期诊断指标,为肿瘤预后程度的判断提供可靠依据,值得临床推广。

Objective To investigate the expression and clinical significance of p53 and EGFR in colorectal adenoma and colorectal cancer.Methods Selected 50 patients with colorectal cancer,colorectal adenoma and normal colonic mucosa who were hospitalized in our hospital from Jan 2017 to Dec 2018,detected p53 and epidermal growth factor(EGFR)in colorectal cancer,colorectal adenoma and normal colonic mucosa,analyzed the relationship between them and the clinicopathological indexes of colorectal cancer,and discussed their role in the development of colorectal cancer.Results The correlation between the expression of p53 and EGFR in colorectal cancer and Dukes stage showed that the positive rate of p53 and EGFR increased with the increase of stage number.The expression of p53 and EGFR in patients was positively correlated with the degree of canceration of colorectal cancer.Conclusion The expression of p53 and EGFR has a direct impact on tumor invasion,metastasis and deterioration.Therefore,the expression of p53 and EGFR can be used as an early diagnostic index in colorectal adenoma and colorectal cancer,which has a good significance and reliable basis for the prognosis of tumor,and it is worth popularizing in clinical practice.