TP与TPF方案诱导化疗对局部晚期鼻咽癌患者血红蛋白和营养状态的影响

Effects of chemotherapy induced by TP and TPF on hemoglobin and nutritional status in patients with locally advanced nasopharyngeal carcinoma

目的探讨TP与TPF方案诱导化疗对局部晚期鼻咽癌患者血红蛋白和营养状态的影响。方法选取我院局部晚期鼻咽癌患者80例,根据治疗方法的不同将其分为TPF组(n=40)与TP组(n=40)。两组均采取诱导化疗后放射治疗,其中TP组采取TP方案诱导化疗,TPF组采取TPF方案诱导化疗。比较两组的治疗效果。结果两组的肿瘤控制率无显著差异(P>0.05)。治疗后,TPF组的血红蛋白水平、体重、白蛋白及总蛋白水平均低于TP组(P<0.05)。TP组的白细胞降低发生率低于TPF组(P<0.05)。结论 TPF方案诱导化疗治疗局部晚期鼻咽癌的临床效果与TP方案相当,但TPF方案对患者血红蛋白及营养状态的影响更为明显,且白细胞降低发生率较高。

Objective To investigate the effects of chemotherapy induced by TP and TPF on hemoglobin and nutritional status in patients with locally advanced nasopharyngeal carcinoma.Methods A total of 80 patients with locally advanced nasopharyngeal carcinoma in our hospital were divided into TPF group(n=40)and TP group(n=40)according to different treatment methods.Both groups were treated with radiotherapy after induction chemotherapy,in which the TP group was treated with TP regimen induction chemotherapy and the TPF group was treated with TPF regimen induction chemotherapy.The therapeutic effects of the two groups were compared.Results There was no significant difference in tumor control rate between the two groups(P>0.05).After treatment,the level of hemoglobin,body weight,albumin and total protein levels in the TPF group were lower than those in the TP group(P<0.05).The incidence of leukocytopenia in the TP group was lower than that in the TPF group(P<0.05).Conclusion The clinical effect of TPF regimen induction chemotherapy in the treatment of locally advanced nasopharyngeal carcinoma is similar to that of TP regimen.However,TPF regimen has more obvious effects on patients'hemoglobin and nutritional status,and has higher incidence of leukocytopenia.