垂体后叶素联合肾上腺素在心肺复苏中的应用效果

Application effect of pituitrin combined with epinephrine in cardiopulmonary resuscitation

目的探讨垂体后叶素联合肾上腺素在心肺复苏中的应用效果。方法以本院急诊科收治的46例呼吸、心跳骤停患者为研究对象,根据治疗方法不同将其分为对照组与观察组,各23例。对照组采用标准剂量肾上腺素进行治疗,观察组采用垂体后叶素联合肾上腺素进行治疗。比较两组患者的白蛋白、乳酸、肿瘤坏死因子-α、白细胞介素-6水平、GCS、APACHEⅡ评分以及远期生存率。结果观察组自主循环恢复后3 d的白蛋白、乳酸、肿瘤坏死因子-α与白细胞介素-6水平均低于对照组(P<0.05)。自主循环恢复即刻,两组患者的GCS评分均高于治疗前,且观察组高于对照组(P<0.05)。观察组患者自主循环恢复即刻与恢复后3 d的APACHEⅡ评分均低于对照组(P<0.05)。观察组治疗后2、4周的生存率高于对照组(P<0.05)。结论在实施心肺复苏救治中采用垂体后叶素和肾上腺素联用方式能够显著改善患者的临床症状及昏迷程度,提高存活率。

Objective To explore the application effect of pituitrin combined with epinephrine in cardiopulmonary resuscitation.Methods A total of 46 patients with respiratory and cardiac arrest admitted in the emergency department of our hospital were seted as study objects and divided into control group and observation group according to different treatment methods,with 23 cases in each group.The control group was treated with standard dose of epinephrine,while the observation group was treated with pituitrin combined with epinephrine.The levels of albumin,lactic acid,tumor necrosis factor-α,interleukin-6,the scores of GCS,APACHE Ⅱ and long-term survival rate were compared between the two group.Results At 3 days after the recovery of spontaneous circulation,the levels of albumin,lactic acid,tumor necrosis factor-αand interleukin-6 in the observation group were lower than those in the control group(P<0.05).Immediately of the recovery of spontaneous circulation,GCS scores of both groups were higher than those before treatment,and that of the observation group was higher than the control group(P<0.05).Immediately of the recovery of spontaneous circulation and 3 days after the recovery of spontaneous circulation,APACHE Ⅱ scores in the observation group were lower than those in the control group(P<0.05).The survival rates at 2 and 4 weeks after treatment in the observation group were higher than those in the control group(P<0.05).Conclusion The combined use of pituitrin and epinephrine during cardiopulmonary resuscitation can significantly improve the clinical symptoms,the degree of coma and the survival rate of patients.